Transfection of 12/15-lipoxygenase effectively alleviates inflammatory responses during experimental acute pancreatitis

Figure 3 Expression of Alox15 attenuates cerulein-induced acute pancreatitis. A: Serum amylase activity; B: Wet/dry weight ratio of pancreas tissue; C: Pathological changes in the pancreas; D: Pathological scores of the pancreas; E: TUNEL assay of pancreatic acinar cells apoptosis, the scale bar represents 100 μm; F: Microscopic quantitation of pancreatic acinar cells apoptosis (under a magnification 200 ×); G: Western blot analysis of cleaved caspase-3 in the pancreas tissue. Differences were assessed using one-way ANOVA and multiple comparisons were determined using Games-Howell test. ^aP < 0.05 vs the control group; ^bP < 0.05 the Alox15-lentiviral vector group vs the control vector group.