Transfection of 12/15-lipoxygenase effectively alleviates inflammatory responses during experimental acute pancreatitis

Figure 2 Expression of Alox15 decreases inflammation in cerulein-induced acute pancreatitis. A: Serum levels of interleukin (IL)-1β; B: Serum levels of monocyte chemoattractant protein-1 (MCP-1); C-F: Pancreatic mRNA expression levels of pro-inflammatory mediators: Tumor necrosis factor-α, IL-1β, IL-6, MCP-1; G: The expression of NF-κB p-P65 in pancreatic tissue. Differences were assessed using one-way ANOVA and multiple comparisons were determined using Games-Howell test. ^aP < 0.05 vs the control group; ^bP < 0.05 the Alox15-lentiviral vector group vs the control vector group. TNF-α: Tumor necrosis factor-α; MCP-1: Monocyte chemoattractant protein-1; IL: Interleukin.