Copyright
©The Author(s) 2024.
World J Gastroenterol. Nov 14, 2024; 30(42): 4532-4543
Published online Nov 14, 2024. doi: 10.3748/wjg.v30.i42.4532
Published online Nov 14, 2024. doi: 10.3748/wjg.v30.i42.4532
Characteristics | Organoid culture successful | Organoid culture unsuccessful | P value |
Sex (male) | 6 (66.7) | 3 (50.0) | 0.622 |
Age (year), mean ± SD | 60.3 ± 3.5 | 69.6 ± 5.4 | 0.088 |
BMI, mean ± SD | 22.7 ± 1.3 | 21.6 ± 1.3 | 0.361 |
Smoking | 3 (33.3) | 1 (17.7) | 0.604 |
Drinking | 3 (33.3) | 1 (17.7) | 0.604 |
Tumor size (cm), mean ± SD | 4.2 ± 0.6 | 3.4 ± 0.3 | 0.159 |
Tumor volume (cm3), mean ± SD | 72.4 ± 24.1 | 29.4 ± 8.8 | 0.085 |
Hypertension | 1 (11.1) | 2 (33.3) | 0.525 |
Diabetes | 4 (66.7) | 1 (16.7) | 0.580 |
Family of history malignancy | 3 (33.3) | 0 (0) | 0.229 |
Personal of history malignancy | 1 (11.1) | 0 (0) | 1.000 |
History of abdominal operation | 1 (11.1) | 1 (16.7) | 1.000 |
Location, head-neck | 5 (55.6) | 4 (66.7) | 0.608 |
Clinical TNM staging, III/IV | 7 (77.8) | 6 (100.0) | 0.622 |
T stage, T3-T4 | 6 (66.7) | 5 (83.3) | 0.245 |
N stage, N1 | 7 (87.5) | 4 (66.7) | 0.538 |
M stage, M1 | 4 (44.4) | 3 (50.5) | 1.000 |
CA19-9 (U/mL), mean ± SD | 774.4 ± 299.4 | 1098.6 ± 382.7 | 0.349 |
CA125, mean ± SD | 34.9 ± 11.5 | 55.3 ± 16.6 | 0.514 |
CEA, mean ± SD | 4.7 ± 1.1 | 4.1 ± 0.7 | 0.372 |
Time from initial diagnosis to puncture biopsy (month), mean ± SD | 2.5 ± 0.8 | 1.0 ± 0.1 | 0.526 |
Ki-67 (%), mean ± SD | 28.9 ± 7.2 | 18.0 ± 3.7 | 0.264 |
IHC, CA19-9 (+) | 7 (100.0) | 5 (83.3) | |
IHC, CEA (+) | 5 (83.3) | 4 (100.0) | 1.000 |
IHC, P53 (+) | 5 (71.4) | 3 (60.0) | 1.000 |
- Citation: Yang JL, Zhang JF, Gu JY, Gao M, Zheng MY, Guo SX, Zhang T. Strategic insights into the cultivation of pancreatic cancer organoids from endoscopic ultrasonography-guided biopsy tissue. World J Gastroenterol 2024; 30(42): 4532-4543
- URL: https://www.wjgnet.com/1007-9327/full/v30/i42/4532.htm
- DOI: https://dx.doi.org/10.3748/wjg.v30.i42.4532