Mapping the evolution of liver aging research: A bibliometric analysis

Figure 11  Holistic model in liver aging research. The figure illustrates the stimuli of liver aging, cellular, structural and functional changes caused by liver aging, and interventions and targets for delaying liver aging. PQQ: Pyrroloquinoline quinone; NMN: Nicotinamide mononucleotide; FABP4: Fatty acid binding protein 4; RAC1, Ras-related C3 botulinum substrate 1; IGF2: Insulin-like growth factor 2; FOXO1: Forkhead box O1; CISD2: CDGSH iron–sulfur domain-containing protein 2; PCSK9: Proprotein convertase subtilisin/kexin type 9; MANF: Mesencephalic-astrocyte-derived neurotrophic factor; SIRT6: Sirtuin 6; SLC13A5: Solute carrier family 13 member 5; HO-1: Heme oxygenase 1; ICAM-1: Intercellular cell adhesion molecule-1; LSECs: Liver sinusoidal endothelial cells; HSCs: Hepatic stellate cells; α-SMA: Alpha-smooth muscle; ROS: Reactive oxygen species; KCs: Kupffer cells; DNMT1: DNA (cytosine-5-)- methyltransferase 1; D + Q: Dasatinib (D) and quercetin (Q); CD32b: Fc gamma receptor IIb; PPARα: Peroxisome proliferator activated receptor alpha; SASP: Senescence-associated secretory phenotype; IL: Interleukin.