Machine learning algorithms able to predict the prognosis of gastric cancer patients treated with immune checkpoint inhibitors

Table 1 Univariate cox proportional hazard analysis for overall survival

Characteristics	OS		PFS
	HR (95%CI)	P value	HR (95%CI)	P value
Sex	1.07 (0.72-1.59)	0.72	1.18 (0.82-1.7)	0.367
Age	0.99 (0.97-1)	0.144	0.98 (0.97-1)	0.024
Operation	0.81 (0.55-1.2)	0.299	0.85 (0.59-1.22)	0.376
Smoking	0.85 (0.56-1.29)	0.444	0.85 (0.58-1.26)	0.425
Alcohol drinking	0.76 (0.46-1.26)	0.285	0.88 (0.56-1.38)	0.575
BMI	0.92 (0.86-0.98)	0.006	0.93 (0.88-0.99)	0.018
Number of metastatic site	1.68 (1.13-2.49)	0.01	1.41 (0.97-2.06)	0.07
LMR	0.91 (0.81-1.01)	0.085	0.93 (0.84-1.03)	0.157
DIR	0.78 (0.23-2.66)	0.696	0.9 (0.29-2.73)	0.846
PNI	0.94 (0.91-0.97)	< 0.001	0.97 (0.94-0.99)	0.019
AGR	0.76 (0.37-1.53)	0.438	0.93 (0.48-1.77)	0.815
APRI	0.91 (0.23-3.59)	0.889	0.78 (0.21-2.87)	0.708
RPR	3.19 (0.34-29.61)	0.308	1.82 (0.19-17.8)	0.607
PLPR	1.18 (1.05-1.33)	0.005	1.13 (1-1.27)	0.055
APR	1.04 (0.96-1.13)	0.359	1.01 (0.93-1.11)	0.757
Eosinophil	1.11 (0.38-3.22)	0.843	1.08 (0.4-2.9)	0.876
Basophilic granulocyte	0.04 (0-202.01)	0.453	0.02 (0-73.72)	0.356
RBC	0.64 (0.48-0.85)	0.002	0.68 (0.52-0.88)	0.004
Mean corpuscular volume	1.02 (0.99-1.04)	0.167	1.02 (1-1.04)	0.098
Mean corpuscular hemoglobin	1.04 (0.98-1.1)	0.192	1.05 (1-1.1)	0.072
Platelet crit	2.49 (0.38-16.37)	0.343	2.46 (0.42-14.41)	0.317
γ-glutamyl transpeptidase	1 (1-1)	0.415	1 (1-1)	0.866
Urea	0.92 (0.82-1.03)	0.136	0.92 (0.83-1.02)	0.132
Creatinine	1 (0.99-1.01)	0.836	1 (0.99-1.01)	0.702
Carbondioxide combining power	1.01 (0.94-1.07)	0.854	1.01 (0.95-1.07)	0.759
Glucose	0.95 (0.85-1.07)	0.41	0.94 (0.84-1.05)	0.263
Kalium ion	0.71 (0.45-1.13)	0.148	0.75 (0.49-1.15)	0.194
Natrium ion	0.98 (0.92-1.04)	0.536	1 (0.94-1.07)	0.917
Chloride ion	0.95 (0.9-1.01)	0.082	0.96 (0.91-1.02)	0.179
Calcium ion	0.25 (0.06-1.05)	0.059	0.5 (0.14-1.78)	0.286
Phosphonium ion	0.9 (0.32-2.52)	0.845	1.04 (0.41-2.68)	0.93
Magnesian ion	0.32 (0.06-1.74)	0.186	0.74 (0.15-3.77)	0.718
Carcinoembryonic antigen	1 (1-1)	0.907	1 (1-1)	0.515
Carbohydrate antigen 199	1 (1-1)	0.193	1 (1-1)	0.441

OS: Overall survival; PFS: Progression-free survival; HR: Hazard ratio; CI: Confidence interval; BMI: Body mass index; LMR: Lymphocyte count/monocyte count; DIR: Direct bilirubin level/indirect bilirubin level; PNI: Serum albumin + 5 × lymphocyte count; AGR: Serum albumin/(serum total protein-serum albumin); APRI: Aspartate aminotransferase level/platelet count; RPR: Red cell distribution width/platelet count; PLPR: Platelet count/(lymphocyte count × serum prealbumin); APR: Alkaline phosphatase level/serum prealbumin; RBC: Red blood cell.