Amlodipine inhibits the proliferation and migration of esophageal carcinoma cells through the induction of endoplasmic reticulum stress

Figure 7 In vivo studies revealed that amlodipine was able to impede Eca109 tumor xenografts. Initially, 1 × 10⁶ Eca109 cells were subcutaneously implanted into the left hind limb of female BALB/c nude mice. After five days, when tumors reached an approximate size of 50 mm³, the mice were orally administered with amlodipine (13 mg/kg/d) or PBS control vehicle once daily via gavage. Following treatment for fifteen days, the mice were euthanized and their respective tumors were excised for further analysis. A and B: Body weight (A) and the growth curves (B) of tumors were compared between the control group and amlodipine group with significant differences observed at ^aP < 0.05 vs Control; C: Physical images of tumor xenografts in each group; D: The xenogeneic tumor weights in each group ^aP < 0.05 vs Control; E: Inhibitory rate of amlodipine on Eca109 xenografts in athymic nude mice ^aP < 0.05 vs Control.