Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe obesity

Figure 1 Volcano plots of associations between histological features of nonalcoholic fatty liver disease and microRNA expression. A: MicroRNAs (miRNAs) associated with nonalcoholic fatty liver disease (NAFLD); B: MiRNAs associated with nonalcoholic steatohepatitis (NASH) relative to nonalcoholic fatty liver; C: MiRNAs associated with ballooning; D: MiRNAs associated with fibrosis; E: MiRNAs associated with lobular inflammation. Solid horizonal line represents P = 0.05, and any dots above the line indicate miRNAs with significant associations. Negative associations are in blue; positive associations are in red; black dots below the solid line represent insignificant miRNAs; higher absolute x-value of a dot indicates greater magnitude of change in miRNA expression in patients with histological progression of NAFLD, either increased (x > 0) or decreased (x < 0); higher y-value of a dot indicates smaller P value of associations. NAFLD: Nonalcoholic fatty liver disease; NASH: Nonalcoholic steatohepatitis.