Current status of magnetic resonance imaging radiomics in hepatocellular carcinoma: A quantitative review with Radiomics Quality Score

Table 1 Characteristics of included studies

Ref.	ST	CP	Specific outcome	NP (type)	Modalities used for feature extraction	Seg	Software used for feature extraction	Features number (type)	FS	CM	Model applied to a separate dataset?	Most important result	Main findings
Liu et al[42], 2023	R	PPF	MVI	104 (HCC)	T2WI	M, 3D	AK SOFTWARE	851 (first order, shape, GLCM, GLSZM, GLRLM, NGTDM, and GLDM)	LASSO, LR	LR	Yes	AUC = 0.867 in the TS, 0.820 in the VS	A prediction model using radiomic features from single T2WI can predict MVI in HCC
Wang et al[43], 2023	R	PR	LRT	100 (HCC)	AP, PVP, T2WI	M, 3D	3D SLICER	851 (first-order, shape, GLCM, GLDM, GLSZM, GLRLM, NGTDM and wavelet)	t-test/Mann Whitney, LASSO	ROC	Yes	AUC = 0.867	MRI-based radiomics analysis may serve as a promising and noninvasive tool to predict outcome of locoregional treatment in HCC patients
Gong et al[44], 2023	R	MC	PD-1/PD-L1	108 (HCC)	T2WI FS, AP, PVP	M, 3D	NS	352 (GLCM, GLRLM, intensity histogram, and shape)	ICC, t-test/ MANN WHYTNEY, LASSO	LR	Yes	AUC = 0.946 in the TS and 0.815 in the VS	A radiomics model based on multisequence MRI has the potential to predict the preoperative expression of PD-1 and PD-L1 in HCC
Zhang et al[45], 2023	R	MC	CK 19+/-HCC	311 (HCC)	T1WI, T2WI, DWI, AP, VP, and DP	M, 3D	uRP	2286 (first order, wavelet)	ICC, LASSO	LR	Yes	in the TS (C-index, 0.914), internal (C-index, 0.855), and external VS (C-index, 0.795)	The combined model based on clinic-radiological radiomics features can be used for predicting CK19+ HCC preoperatively
Zhang et al[46], 2023	R	PPF	MTM HCC	232 (HCC)	DCE-MRI	M, 3D	Pyradiomics	1037 (first order, shape GLRLM, GLSZM, NGTDM, GLCM, GLDM LoG and wavelet)	ICC, GBDT	LR, KNN, Naive-Bayes, Decision Tree, SVM	Yes	AUCs of 0.896 and 0.805 in the TS e VS	The nomogram containing radiomics, age, alpha-fetoprotein, tumour size, and tumour-to-liver ADC ratio revealed excellent predictive ability in preoperatively identifying the MTM-HCC Subtype
Dong et al[47], 2024	R	D, PR	VETC	221 (HCC)	DCE-MRI	M, 3D	Pyradiomics	1218 (FIRST ORDER)	ICC	LR, decision tree, RF, SVM, KNN, and Bayes	Yes	AUC = 0.844	The DLR model provides a noninvasive method to discriminate VETC status and prognosis of HCC patients preoperatively
Tabari et al[48], 2023	R	PPF	Pre-ablation tumor radiomics	97 (HCC)	AP, DCE-MRI	M, 3D	NS	112 first-order, (GLCM, GLDM, GLRLM, GLSZM, NGTDM)	mRMR	RF	Yes	AUC = 0.83	Pre-ablation MRI radiomics could act as a valuable imaging biomarker for the prediction of tumor pathologic response in patients with HCC
Cao et al[49], 2023	R	PR	RFS	249 (HCC)	T2WI FS, T1WI FS, DCE-MRI	M, 3D	Pyradiomics	NS (first-order, shape, and texture, wavelet, Laplacian)	LASSO	Cox regression	Yes	C-index = 0.893 TS, 0.851 (test set), 0.797 (external)	The combined radiomic model provides superior ability to discern the possibility of recurrence-free survival in HCC over the total radiomic and the clinical–radiological models
İnce et al[50], 2023	R	PPF	TARE	82 (HCC)	DCE-MRI	S, 3D	Pyradiomics	1128 (first-order, GLCM, GLDM, GLRLM, GLSZM, and NGTDM)	ICC, PCA, SFS	SVM, LR, RM, LightGBM	No	AUC = 0.94	Machine learning–based clinicoradiomic models demonstrated potential to predict response to TARE
Chen et al[51], 2023	R	PR	TACE	144 (HCC)	T2WI, AP, PVP, DP	M, 3D	Pyradiomics	110 (NS)	mRMR, LASSO, DNN	SVM, LR	Yes	AUC = 0.974	DNN model performs better than other classifiers in predicting TACE response. Integrating with clinically significant factors, the CD model may be valuable in pre-treatment counseling of HCC patients who may benefit the most from TACE intervention
Jiang et al[52], 2023	R	PPF	MVI	102 (HCC)	T1_in, T1_A, T2W, DWI	M, 3D	Pyradiomics	1967 (first-order, shapes, textures, GLCM, GLSZM, GLDM, GLRLM, and filter-transformed)	LASSO	ULR	Yes	AUC = 0.901, 0.923 for TS and VS	The multiparametric MRI-based radiomics nomogram is a promising tool for the preoperative diagnosis of peritumoral MVI in HCCs
Hu et al[53], 2023	R	D, MC	CK19+	110 (HCC)	AP, VP, HBP	M, 3D	PyRadiomics	1130 (shape, first order, GLCOM, GLRLM, GLSZ, GLDM)	ICC	RFE	No	AUC = 0.92	The established radiomics signature based on preoperative gadoxetic acid-enhanced MRI could be an accurate and potential imaging biomarker for HCC CK19 (+) prediction
Chong et al[54], 2023	R	MC, PR	Glypican 3-Positive HCC	259 (HCC)	T2WI, DWI, PRE, AP, PVP, TP and HBP	M, 3D	PyRadiomics	749 (first order statistics, shape and size) and textural property types (GLSZM, GLCM, GLDM, GLRLM, and NGTDM)	Test-retest procedure, ICC, LASSO, RF, SVM	LR, RF, SVM	Yes	AUC = 0.943 vs 0.931 TS and VS respectively	Preoperative EOB-MRI radiomics-based nomogram satisfactorily distinguished GPC3 status and outcomes of solitary HCC 5 cm
Hu et al[55], 2023	R	D, PPF	Functional liver reserve	403 (HCC)	DCE MRI	M, 3D	Pyradiomics	851 (shape, first-order GLCM, GLRLM, GLSZ, GLDM, NGTDM, wavelet)	ICC, Spearman’s correlation	LR, SVM	No	AUC = 0.71	A radiomics model based on gadoxetic acid-enhanced MRI was constructed in this study to discriminate HCC with different histopathologic grades
Tao Y et al[56], 2023	R	MC	PD-L2	108 (HCC)	T2WI, AP, PV	M, 3D	R	1130	ICC, LASSO	ROC	No	AUC = 0.871	Prediction based on the radiomic characteristics of MRI could noninvasively predict the expression of PD-L2 in HCC
Yang et al[57], 2022	R	PR	ER	181 (HCC)	T1WI, T2WI	M, 3D	LIFEx	34 (Histogram, Shape)	LASSO	ROC	Yes	AUC = 0.79	The model for early recurrence of HCC after ablation based on the clinical, imaging, and radiomics features presented good predictive performance
Liu et al[58], 2023	R	PPF	MVI	161 (HCC)	AP, PVP, DP	M, 3D	3D Slicer, Pyradiomics	321 (shape, first-order histogram, GLCM, GLDM, GLRLM, GLSZM, NGTDM)	LASSO, ICC	LR	Yes	AUC = 0.87	The nomogram model can effectively predict MVI in patients with HCC
Zhang et al[59], 2022	R	PPF	MVI	189 (HCC)	HBP	M, 3D	IBEX SOFTWARE	1768	LASSO, ICC	nomogram	Yes	AUC = 0.884	Depending on the clinicoradiological factors and radiological features, nomograms can effectively predict MVI status in HCC patients
Sim et al[60], 2022	R	PPF	MVI	50 (HCC)	T1 AP, T1PVP	M, 2D	MaZda	290 (area, histogram, gradient, GLCM, GLRLM, autoregressive, and wavelet)	Mutual Information, recursive pruning	SVM	No	Accuracy = 0.878	Texture analysis of tumours on pre-operative MRI can predict presence of MVI in HCC
Zhang et al[61], 2022	R	PR	RFA, ER	90 (HCC)	T1WI, T2WI, CE-MRI	M, 2D	AK Software	1316 (first-order histogram, shape, texture, GLCM, GLRLM, GLSZM, NGTDM, GLDM, and local binary pattern, high-order, and wavelet)	ANOVA	RF, LASSO	Yes	AUC of 0.822 in the TS and 0.812 in the VS	The multi-parametric MRI-based radiomics nomogram has a high predictive value for ER of small HCC after RFA
Zhao et al[62], 2023	R	PR	HAIC	112 (HCC)	T2WI	M, 3D	AK software	396 (histogram, form factor, texture, GLZSM, GLCM, GLRLM, and Haralick)	LASSO	ROC	Yes	Accuracy = 0.81	The nomogram based on the combined model consisting of MRI radiomics and ALBI score could be used as a biomarker to predict the therapeutic response of unresectable HCC after HAIC
Lu et al[63], 2022	R	PPF	MVI	165 (HCC)	T2WI, DWI (b = 800 s/mm2), T1WI, AP, PP, TP, and HBP	M, 3D	Pyradiomics	1227 (shape, first-order, texture, GLSZM, GLRLM, GLCM, NGTDM, and GLDM)	LASSO	multivariate LR	Yes	AUC = 0.826	The combined model based on radiomics features of Gd-EOB-DTPA enhanced MRI, tumour margin, and peritumoural hypointensity was valuable for predicting HCC MVI
Yang et al[64], 2022	R	PPF	MVI	110 (HCC)	DCE-MRI	M, 3D	A.K. Software	11 (Grey Histogram, GLCM)	NO	ROC	No	AUC = 0.797	The combination of MR image features and texture analysis may improve the efficiency in prediction of MVI
Ameli et al[65], 2022	R	D	Degree of tumor differentiation	129 (HCC)	ADC, VE MAPS	S, 3D	MATLAB R2017B	95 (global, histogram, GLCM, GLRLM, GLSZM, NGTDM)	multi-class classification algorithm	RF	Yes	AUC = 0.832	The addition of radiomics-based texture analysis improved HCC grading over that of ADC or venous enhancement values alone
Li et al[66], 2022	R	PR	ER	302 (HCC)	T2WI, DWI (800 s/mm2), AP, and PVP	M, 3D	Pyradiomics	853 (shape, first order, texture, and wavelet)	SPSS, LASSO, ICC	ROC	Yes	AUCs of 0.91 and 0.87 in the TS and VS	The proposed predictive model incorporating clinico-radiological factors and the fusion radiomics signature derived from multiparametric MR images may be an effective tool for the individualized prediction of postoperative ER in patients with HCC
Zeng et al[67], 2022	R	PPF	BETA-CATENIN MUTATION	98 (HCC)	AP, PVP, DP, HBP	M, 3D	Pyradiomics	1674 (first order, GLCOM, GLSZM, GLRLM, GLDM)	T-test, fisher's exact test	LSVC	Yes	AUC = 0.86	The RHBP radiomics model may be used as an effective model indicative of HCCs with b-catenin mutation preoperatively
Aujay et al[68], 2022	R	PR	TARE	22 (HCC)	AP, PVP	M, 3D	Pyradiomics	107 (Shape, first- and second- order)	Mann-Whitney U test	LR	No	AUC = 0.92	Radiomics could aid in the prediction of early treatment response following TARE in patients with HCC
Chen et al[69], 2022	R	PPF	MVI	415 (HCC)	T1WI, T2WI, DWI, AP, PVP, HBP	M, 3D	R	1409 (First order, shape, two order texture, Laplacian, wavelet, logarithmic, and exponential filters)	LASSO	SVM, XGBoost, RF, LR	Yes	AUC = 0.979	Machine learning with an LR classifier yielded the best radiomics score for HBP and DWI. The radiomics nomogram developed as a noninvasive preoperative prediction method showed favorable predictive accuracy for evaluating MVI in sHCC
Wu et al[70], 2023	R	D	DP-HCC	179 (DPHCC, non DPHCC)	DCE-MRI	M, 3D	PyRadiomics	1781 (first-order statistics, shape, and texture)	PCC, RFE	SVM, LR, LR-LASSO	Yes	AUC = 0.908	MRI radiomics models may be useful for discriminating DPHCC from non-DPHCC before surgery
Li et al[71], 2022	R	PPF	MVI	113 (HCC)	T2WI, T1WI, DCE MRI	M, 2D	MaZda	101 (histogram, GLCOM, GLRLM)	t-test, Mann-whitney U test	ROC	No	AUC = 0.939	Noninvasive MRI radiomic model based on MDF values and imaging biomarkers may be useful to make preoperative prediction of MVI in patients with primary HCC
Wang et al[72], 2022	R	PR	ER	190 (HCC)	T2WI, T2WI FS, DCE MRI	M, 3D	PyRadiomics	1316 (first-order histogram, texture, shape, GLZSM, GLRLM, GLCM, GLDM, and NGTDM, wavelet, local binary pattern, and Laplacian of Gaussian)	ICC, LASSO	LASSO, ICC, LR	Yes	AUC = 0.90	The predictive model incorporated the clinical–radiological risk factors and radiomics features that could adequately predict the individualized ER risk in patients with solitary HCC ≤ 5 cm
Zhang et al[73], 2023	P	PPF	MVI	602 (HCC)	T1WI, T2WI, AP, VP, HBP and ADC	M, 3D	Radcloud platform	1409 (First order, second order, shape, texture)	LASSO	LR, RF, SVM	Yes	AUC = 0.824 E 0.821 in the TS and VS	The combination of clinicoradiological factors and fusion radiomics signature of AP and VP images based on Gd-EOB-DTPA-enhanced MRI can effectively predict MVI
Brancato et al[74], 2022	R	PPF	IABR	38 (HCC)	T2WI, DCE-MRI	M, 3D	Pyradiomics	386 (shape, first-order, and texture)	correlation filter, Wilcoxon-rank sum test, MI	LR	No	AUC = 0.96	Radiomics MRI based on T2 and DCE-MRI revealed promising results concerning both HCC detection and grading
Fan et al[75], 2022	R	PR	VEGF	202 (HCC)	AP, PV, HBP, BP, DP	M, 3D	PyRadiomics	1906 (first order, shape)	ICC, ANOVA	LR	Yes	AUC = 0.892 in the TS, 0.800 in the VS	The combined model acquired from Gd-EOB-DTPA enhanced MRI could be considered as a credible prognostic marker for the level of VEGF in HCC
Gao et al[76], 2022	R	PPF	MVI	115 (HCC)	T2WI, T1WI, AP, PVP, DP, and HBP	M, 3D	Pyradiomics	107 (shape, first-order, and textural)	LR, SVC, RFC, and AdaBoost	LR	Yes	AUCs of 0.866 in the TS and 0.855 in the VS	The fusion model of multi-region radiomics achieves an enhanced prediction of the individualized risk estimation of MVI in HCC patients
Hu et al[77], 2022	R	PPF	MVI	501 (HCC)	T1WI, AP, PVP, HBP	M, 3D	Pyradiomics	2600 (first order, shape, GLCM, GLRLM, GLSZM, GLDM and NGTDM)	LASSO	ROC	Yes	AUC = 0.962	The radiomics signatures of the dual regions for tumor and peritumor on AP and PVP images are of significance to predict MVI
He et al[78], 2022	R	PR	DFS, OS	103 (HCC)	DCE MRI	M, 2D	AK software	1217 (First order, Morphological, GLCM, GLRLM, GLSZM, GLDM, LOG)	ICC, Lasso, cox regression	LASSO	Yes	AUC = 0.884	Multimodal radiomics models can serve as effective visual tools for predicting prognosis in patients with liver cancer
Ren et al[79], 2023	R	PR	HCC grade	270 (HCC)	T2WI	M, 3D	Pyradiomics	1197 (first-order and shape, GLCM, GLRLM, GLRM, and spatial gray scale corre-lation matrix)	MIC, Spearman’s correlation, LR	LR	Yes	AUC = 0.864	The clinical–radiomics model integrating radiomics features and clinical factors can improve recurrence predictions beyond predictions made using clinical factors or radiomics features alone
Luo et al[80], 2022	R	PR	TACE	61 (HCC)	T1WI, T1WI AP, T1WI PP, T2WI, DWI (b = 800), ADC	M, 3D	Pyradiomics	1782 (shape, GLCM, GLRLM, GLSZM, NGTDM)	RF, single cox regression	ROC	No	AUC = 0.71	Radiomic signatures derived from pretreatment MRIs could predict response to combined Lenvatinib and TACE therapy. Furthermore, it can increase the accuracy of a combined model for predicting disease progression
Wang et al[81], 2022	R	PPF	MVI	113 (HCC)	AP	M, 3D	MATLAB	12 (first order)	NO	Mann-Whitney U test, LR	No	AUC = 0.741	Peritumoral AP enhanced degree on MRI showed an encouraging predictive performance for preoperative prediction of MVI
Mao et al[82], 2022	R	PPF	HCC GRADE	122 (HCC)	T2WI (AP, HBP phases)	M, 3D	Image Analyzer	121 (histogram, shape, texture, GLRLM and GLCM)	ICC	ANN, LR	Yes	AUC = 0.889	Prediction models consisting of clinical parameters and Gd-EOB-DTPA-enhanced MRI radiomic features could distinguish between high-grade HCCs and low-grade HCCs
Anderson et al[83], 2023	P	PR	IVIM	17 (HCC)	DWI-MRI	M, 2D	Matlab	3 (10th, 50th, and 90th percentiles)	NO	Wilcoxon signed-rank test	No	NS	DW-MRI with IVIM and histogram analysis revealed significant reductions of D* early after treatment as well as an association between D at baseline and smaller tumor growth at three months
Li et al[84], 2022	R	PPF	SEV, MVI	43 (HCC)	DWI, DCE-MRI	M, 2D	Matlab, SPSS, Medcalc	8 (Histogram)	NO	ROC	No	AUC = 0.863	Histogram parameters DDC and ADC, but not the α value, are useful predictors of MVI. The fifth percentile of DDC was the most useful value to predict MVI of HCC
Li et al[85], 2022	R	PPF	MVI	301 (HCC)	T1WI, T2WI	M, 3D	MITK SOFTWARE	328 (first-order, GLCM, GLRLM, form factor)	LASSO, ANOVA, MANN-WHITNEY TEST	LASSO	Yes	AUC = 0.914	The preoperative MRI-based radiomic-clinical model predicted the MVI of HCC effectively and was more efficient compared with the radiomic model or clinical model alone
Wang et al[86], 2022	R	D	DD (cCC-HCC, HCC, CC)	196 (33 cHCC-CC, 88 HCC and 75 CC)	DCE (ART, PVP, DP)	M; 3D	Pyradiomics	1316 (shape, first-order, texture -GLCM, GLSZM, GLRLM, GLDM, NGTDM- from original, LoG and wavelet filtered images)	MI, F-test, Chi2-test, LASSO	SVM	No	AUC = 0.91	The classification ability of cHCC-CC, HCC and CC can be further improved by extracting MRI high- order features and using a two-level feature selection method
Yang et al[87], 2021	R	PPF	MVI	201 (HCC)	DCE (Pre-T1WI, AP, PVP, DP and HBP)	S; 3D	AK software	851 (shape, first-order, texture-GLCM, GLSZM, GLRLM, GLDM, NGTDM-, wavelet-transformed)	mRMR, LASSO	ROC; LR	Yes	Radiomics: AUC = 0.896 (TS), 0.788 (VS); Radiomics + clinical: AUC = 0.932 (TS), 0.917 (VS)	The preoperative nomogram integrating clinicoradiological risk factors and the MR radiomics signature showed favourable predictive efficiency for predicting MVI
Lv et al[88], 2021	R	PR	AIR of RFA-treated HCC	58 (HCC)	DCE	S; 3D	AK software	396 (histogram, GLCM, GRLM, GLSZM, formfactor)	LASSO	LASSO, ROC	Yes	AUC = 0.941 and 0.818 in the TS and VS	The predictive nomogram integrated with clinical factors and CE-T1WI -based radiomics signature could accurately predict the occurrence of AIR after RFA
Yu et al[89], 2022	R	PPF, PR	VECT, PFS in VETC + and VETC-patients	182 (HCC)	HBP	M; 3D	Pyradiomics	1316 (shape, first-order, texture-GLCM, GLRLM, GLSZM, GLDM, NGTDM-)	LASSO	Multivariate LR; forest, SVM; DT	Yes	AUC = 0.972 (peritumoral radiomics model), AUC = 0.91 (intratumoral model)	The intratumoral or peritumoral radiomics model may be useful in predicting VETC and patient prognosis preoperatively. The peritumoral radiomics model may yield an incremental value over intratumoral model
Fang et al[90], 2021	R	PR	PFS of TACE + RFA treated HCC	113 (HCC)	DCE (HAP, PVP, SPP, and DP)	S; 3D	AK software	396 (histogram, GLCM, GLSZM GRLM)	LASSO	Cox regression; ROC	Yes	C-index radiomics: 0.646 and 0.669 in TS and VS; C-index combined model: 0.772 and 0.821 in TS and VS	A nomogram combining radiomics and clinical factors predicted the PFS of intermediate and advanced HCC treated with TACE plus RFA
Yang et al[91], 2021	R	MC	CK19+ HCC	257 (HCC)	T2WI; DWI	M; 3D	MATLAB	968 (shape, first-order, texture-GLCM, GLRLM, GLSZM, NGTDM-, wavelet)	Univariate analysis, mRMR	Multiple LR; SVM; RF; ANN	Yes	ANN-model: AUROCs = 0.857, 0.726, and 0.790 in the TS and VS A and B	The combined model based on mpMRI-radiomics accurately classify CK19+ HCC
Chen et al[92], 2021	R	MC	CK19+ HCC	141 (HCC)	HBP	S; 3D	Python (U-Net)	1024 (Deep semantic)	grid search	GBDT	Yes	AUC = 0.820 and 0.781 in TS and VS	DCE-MRI-based radiomics DLR model can preoperatively predict CK19-positive HCCs
Horvat et al[93], 2021	R	PR	Sustained complete response in RFA-treated HCC	34 (HCC)	DCE (AP and EP)	M; 3D	Pyradiomics	107 (shape, first-order, texture-GLDM, NGTDM, GLSZM, GLCM-)	NO	ROC	No	AUC > 0.7	Second-order features extracted from equilibrium phase obtained highest discriminatory performance
Alksas et al[94], 2021	R	D	DD (types and grades of liver tumors)	95 (38 benign tumors, 19 intermediate tumors, 38 HCC)	DCE (Pre-T1WI, LAP, PVP, and DP)	M; 3D	NS	249 (morphological, functional, first-order, texture-GLCM, GLRLM-)	Wrapper approach, and Gini impurity-based selection	RF; SVM; NB, KNN; LDA	No	Accuracy = 0.88	The identified imaging markers and CAD system can early and accurately detect and grade liver cancer
Chong et al[95], 2021	R	PR	2 yr RFS after hepatectomy	23 (HCC)	DCE (AP, PVP, TP, HBP)	M; 3D	Pyradiomics	2950 (shape, first-order, texture-GLCM, GLRLM, GLSZM, GLDM, NGTDM- from original and filtered images -Wavelets, Gaussian, Laplacian Sharpening-)	Inter-correlation, LASSO	LR, RF, SVM	Yes	AUC = 0.93 and 0.84 in TS and VS	DCE-MRI-based peritumoral dilation radiomics is a potential preoperative biomarker for early recurrence of HCC patients without MVI
Ding et al[96], 2021	R	D	DD (HCC vs FNH)	224 (149 HCC, 75 FNH)	AP and PVP	M; 3D	Pyradiomics	2260 (shape, first-order, texture -GLDM, GLCM, GLRLM, GLSZM, NGTDM-, from original LoG and wavelet filtered images)	mRMR, RF, correlation, LASSO	LR	Yes	AUC combined model = 0.984 and 0.972 in TS and VS	The combined model can differentiate HCC from FNH in non-cirrhotic liver with higher accuracy than the clinical model
Fan et al[97], 2021	R	MC	Ki67+ HCC	51 (HCC)	DCE (AP, PVP, HPB); T2WI	M; 3D	Pyradiomics	1300 (shape, first-order, texture -GLCM, GLSZM, GLRLM, GLDM, NGTDM- from original, LoG and wavelet filtered images)	LASSO	LR	Yes	Combined model: AUC = 0.922 (TS) and 0.863 (VS)	Combined AP-Rad-score-serum AFP model can preoperatively predict Ki-67 expression in HCC and outperforms AP-based radiomics model
Gao et al[98], 2021	R	PPF	MVI	225 (HCC)	T2WI	M; 3D	Matlab, SE-DenseNet	180 low level (intensity, shape, GLCM, GLRLM) + high-level semantic with CNN	LASSO	LR, KNN, RF, SVM, CNNs	Yes	AUC = 0.826	The proposed ensemble learning algorithm is proved to be an effective method for MVI prediction
Li et al[99], 2022	R	MC	GOLM1, SETD7, and RND1 expression levels	92 (HCC)	T2WI	M; 2D	MATLAB	307 (first-order statistics, GLCM, GLRLM, GLSZM, NGTDM), with five, LBP, fractal analysis, shape metrics, FOS, variance, power)	Correlation, RELIEFF	SVM	Yes	r = 0.67	MRI radiomics features could help quantify GOLM1, SETD7, and RND1 expression levels and predict the recurrence risk for early-stage HCC patients
Shi et al[100], 2022	R	PR	Functional liver reserve	60 (HCC)	HBP	M; 3D	QTIELAB	165 (shape, histogram, texture-GLCM, GLRLM, GLZSM-)	Boruta algorithm	RF	No	AUC = 0.90, 0.95, 0.99 for ICG R15 < 10%, < 15%, and < 20%	Radiomics analysis of Gd-EOB-DTPA enhanced hepatic MRI can be used for assessment of functional liver reserve in HCC patients
Dai et al[101], 2021	R	PPF	MVI	69 (HCC)	DCE (Pre-T1WI, AP, PVP or HBP)	M; 3D	Matlab	106 (texture -GLCM, GLRLM, GLSZM, SGLDM, NGTDM, and NGLDS-)	LASSO, SVM-RFE, mRMR, LASSO-RFE	GBDT; SVM; LR; RF	No	AUC = 0.792 for HBP model	The radiomics model based on the HBP had better predictive performance than those based on the AP, PVP, and pre-enhanced T1W
Fan et al[102], 2021	R	PPF	VECT+ HCC	81 (HCC)	DCE (AP and HBP)	M; 3D	Pyradiomics	1316 (first-order, texture -GLCM, GLSZM, GLRLM, GLDM, NGTDM- from original, wavelet and LoG filtered images)	ICC, LASSO	ROC; LR	No	AUC = 0.84	Texture analysis based on Gd-EOB-DTPA-enhanced MRI can help identify VETC-positive HCC
Yang et al[103], 2021	R	PPF	Poorly differentiated HCC	188 (HCC)	T1WI, T2WI, DCE (AP, PP and DP)	M; 3D	LIFEx	200 (shape, histogram, texture -GLCM, NGLDM, GLRLM, GLZLM-)	LASSO	LASSO	Yes	Model1: AUC = 0.623 and 0.576 in TS and VS, while it is 0.576 in the validation cohort. Model2: AUC = 0.721, and 0.681 in TS and VS	The MRI-based radiomics signature and clinical model can distinguish HCC patients that belong in a low differentiation group fromother patients
Chen et al[104], 2021	R	PPF	MVI	269 (HCC)	T2WI; DWI, DCE (AP, PVP, and HBP)	M; 3D	Pyradiomics	1395 (first-order, GLRLM, GLCM from original, Laplacian, logarithmic, exponential, and wavelet filtered images)	Variance threshold, LASSO	KNN SVM, XGBoost, RF, LR, DT	Yes	For HBP model: AUC = 0.942 (SVM), 0.938 (XGBoost), and 0.936 (LR)	Radiomics signatures with machine learning can further improve the ability to predict MVI and are best modeled during HBP
Kong et al[16], 2021	R	PR	Response to TACE	99 (HCC)	T2WI	M; 3D	AK software	396 (histogram, texture-GLSZM, GLCM, GLRLM-)	LASSO, correlation	ROC	Yes	AUC = 0.861 and 0.884 in TS and VS	The radiomics and clinical-based nomogram can well predict TR in intermediate-advanced HCC
Zhao et al[105], 2021	R	MC	GPC3	143 (HCC)	DCE-MRI, DWI	M; 3D	MedCalc, R	6 (Histogram)	NO	Mann-Whitney U test	No	C-INDEX = 0.804	Elevated serum AFP levels and lower 75th percentile ADC values were helpful in differentiating GPC3-positive and GPC3-negative HCCs. The combined nomogram achieved satisfactory preoperative risk prediction of GPC3 expression in HCC patients
Song et al[106], 2021	R	PPF	MVI	601 (HCC)	T2WI FS; DWI; ADC; DCE (AP, PVP, and DP)	M; 3D	PyRadiomics	110 (shape, first-order, texture)	PCA, ANOVA	SVM, AE, LDA, RF, LR, LASSO, AdaBoost, DT, Gaussian process, NB, DL	Yes	DLC model: AUC = 0.931 for MVI prediction; AUC = 0.793 for MVI-grade stratification	DLC model predicts and grades MVI better than DL model
Zhong et al[107], 2021	R	D	DD (small HCC 3 cm vs benign nodules)	150 (112 HCC, 44 benign nodules)	in phase sequence; T2WI FS; ADC	M; 2D	MaZda	837 (histogram, GLCM, RLM, wavelet, absolute gradient, autoregressive model)	ICC, Mann-Whitney, LASSO	LR; ROC	No	AUC = 0.917	MRI-based radiomics analysis showed additive value to the LI-RADS v 2018 algorithm for differentiating small HCCs from benign nodules in the cirrhotic liver
Zhao et al[105], 2021	R	MC	GPC3 expression	143 (HCC)	ADC	M;3D	MR Multiparametric Analysis software	6 (histogram)	Univariate analysis (t-test, Mann-Whitney, Pearson, χ2, Fisher)	LR	No	C-index = 0.804	The combined nomogram achieved satisfactory preoperative risk pre-diction of GPC3 expression in HCC patients
Chen et al[108], 2021	R	PR	Post hepatectomy liver failure	144 (HCC)	HBP	M; 2D	AK software	1,044 (shape, first-order, texture-GLSZM, GLCM, GLRLM-)	Correlation, RFE	LR; ROC; liver failure model	Yes	AUC = 0.956 and 0.844 in TS and VS	The LF model is able to predict PHLF in HCC patients
Liang et al[109], 2021	R	PPF	MVD	30 (HCC)	DCE	M; 2D	AK software	376 (histogram, texture-GLSZM, GLCM, GLRLM-)	Mann-Whitney	LR	No	AUC = 0.83 and 0.94	DITET model provides a better indication of the microcirculation of HCC than SITET
Zhang et al[110], 2021	R	PR	RFS of HCC patients treated with surgical resection	153 (HCC)	T2WI FS; DCE (AP, PVP, and HBP)	M; 3D	Pyradiomics	107 (shape, first-order, texture -GLCM, GLSZM, GLRLM, GLDM, NGTDM-)	LASSO	LASSO Cox regression	Yes	C-index 0.725	The prediction model combining MRI radiomics signatures with clinical factors predicts the prognosis of surgically resected HCC patients
Zhang et al[111], 2021	R	PR	RFS after curative ablation	132 (HCC)	T2WI FS; T1WI FS; DCE (AP, PVP, and HBP)	M; 3D	Pyradiomics	1316 (shape, first-order, texture -GLCM, GLSZM, GLRLM, GLDM, NGTDM-, LoG, wavelet)	RandomForestSRC	Cox regression; random survival forest; ROC	Yes	C-index = 0.706	The radiomics model combining DCE-MRI with clinical characteristics could predict HCC recurrence after curative ablation
Zhang et al[112], 2021	R	PPF	MVI	195 (HCC)	T2WI FS; DWI; ADC; DCE (AP, PP, DP)	M; 3D	AK software	396 (histogram, GLCM, GLSZM, RLM, formfactor, haralick)	ANOVA, Mann-Whitney U-test, correlation, LASSO	Multivariate LR	Yes	AUC = 0.901 and 0.840 in the TS and VS	The combined radiomics-clinical model can preoperatively and noninvasively predict MVI in HCC
Zhao et al[113], 2021	R	PR	Response to TACE	122 (HCC)	DCE (AP, PVP, and DP)	M; 3D	AK software	789 (histogram,GLCM, GLRLM, GLZSM, Haralick,Gaussian transform)	ICC, Spearman's correlation, univariate LR, LASSO	LR; ROC	Yes	AUC = 0.838 and 0.833 in TS and VS	The combined model (radiomics score + clinical-radiological risk factors) showed better performance than the clinical-radiological model in predicting TACE efficacy in HCC patients
Kuang et al[114], 2021	R	PR	Predict short-term response after TACE in HCC	153 (HCC)	T2WI; DCE (AP)	A; 3D	AK software	396 (shape, histogram, GLSZM, GLCM, RLM)	mRMR, LASSO	LR	Yes	AUC = 0.83 and 0.81 in TS and VS	MRI-based nomogram has greater predictive efficacy to predict the response after TACE than radiomics and clinics models alone
Meng et al[115], 2021	R	PPF	MVI	402 (HCC)	T1WI, T2WI, DWI, CE-CT	M, 3D	Pyradiomics	1288	ICC, MANN-WHITNEY, LASSO	LR	Yes	AUC = 0.804	CT and MRI had a comparable predictive performance for MVI in solitary HCC. The RS of MRI only hadsignificant added value for predicting MVI in HCC of 2–5 cm
Zhu et al[116], 2021	R	D	DD (MTM-HCC vs HCC)	88 (32 MTM-HCCs, 56 Non-MTM-HCC)	T2WI FS; in-phase and out-of-phase sequences; DCE (AP, PVP, and DP)	M; 2D	MaZda	101 (histogram, the absolute gradient, GLRLM, GLCM, autoregressive model and wavelet transform)	Fisher, MI, POE + ACC, LASSO	LR; ROC	No	AUC = 0.785	A DCE-MRI-based radiomics nomogram can predict MTM-HCC
Liu et al[117], 2021	R	PR	TACE, MWA	102 (HCC)	T1WI, T2WI, PVP	M, 2D	MaZda	20 (First order, GLCM)	NS	ROC	No	AUC = 0.876	MR imaging texture features may be used to predict the prognosis of HCC treated with TACE combined with MWA
Chong et al[118], 2021	R	PR	MVI, RFS after curative surgery (HCC≤ 5 cm)	356 (HCC)	DWI, DCE (Pre-T1WI, AP, PVP, TP, HBP)	M; 3D	Pyradiomics	854 (shape, first-order, texture -GLCM, GLDM, GLRLM, NGTDM, GLSZLM- from original and wavelet filtered images)	LASSO	RF; LR	Yes	AUC = 0.920 with RF, 0.879 with LR in validation cohort	Preoperative radiomics-based nomogram using random forest is a potential biomarker of MVI and RFS prediction for solitary HCC ≤ 5 cm
Gu et al[119], 2020	R	MC	GPC3+ HCC	293 (HCC)	DCE (DP)	M; 3D	Pyradiomics	853 (shape, histogram, texture -GLCM, GLSZM, GLRLM, GLDM, NGTDM-, wavelet)	ICC, Mann-Whitney, Fisher	LR; SVM	Yes	AUC = 0.926 and 0.914 in TS and VS	The combined AFP + radiomics nomogram may provide an effective tool for noninvasive and individualized prediction of GPC3-positive in HCC patients
Zhao et al[120], 2021	R	PR	ER after partial hepatectomy	113 (HCC)	T2WI; in-phase and out-of-phase sequences; DWI; DCE (AP, PVP, and DP)	M; 3D	AK software	1146 (shape, histogram, texture -GLCM, GLRLM, GLSZM-)	Spearman's correlation, LASSO, stepwise LR	Multivariate LR	Yes	Radiomics: AUC = 0.771 in the VS. Combined nomogram: AUC = 0.873	A combined nomogram incorporating the mpMRI radiomics score and clinicopathologic-radiologic characteristics can predict ER (≤ 2 yr) in HCC
Ai et al[121], 2020	R	D	DD (HCC, HH, HC)	89 (33 HH, 22 HC, 34 HCC)	IVIM	M; 3D	MITK-DI	13 (histogram)	Kruskal-Wallis	ROC	No	AUC = 0.883	A multiparametric histogram from IVIM is an effective means of identifying HH, HC, and HCC
Shaghaghi et al[122], 2021	R	PR	Post-TACE OS and TFS	104 (HCC)	ADC	S; 3D	NS	3 (mean, skewness, and kurtosis)	NO	NO	No	Significant results for changes in ADC mean and Kurtosis	Changes in mean ADC and ADC kurtosis can be used to predict post-TACE OS and TFS in well-circumscribed HCC
Li et al[123], 2020	R	D	DD (HCC vs HMRC)	75 (41 HCC, 34 HMRC)	DCE	M; 2D	OmniKinetic	67 (First order, histogram, GLCM, Haralick, RLM)	t-test, ROC	FDA	No	AUC = 0.86 (radiomics + pharmacokinetic) and 0.89 (DA based on radiomics)	A model based on DCEMRI radiomics and pharmacokinetic parameters was useful for differentiating HCC from HMRC
Geng et al[124], 2021	R	PPF, MC	MVI; GRADE; CK-7, CK-19, GPC3 expression status	53 (HCC)	SWI	M;3D	PyRadiomics	107 (first-order, shape, GLCM, GLRLM, GLSZM, NGTDM)	ICC	LR	No	AUC = 0.905 (CK-19+), 0.837 (CK-7+), 0.800 (high histopathologic grade) and 0.760 (GPC-3+)	Extracting the radiomics features from SWI images was feasible to evaluate multiple histo-pathologic indexes of HCC
Zhang et al[125], 2020	R	PR	OS after surgical resection	136 (44 MCC, 59 HCC, 33 CHCC)	DCE (EP); DWI	M; 3D	AK software	384 (histogram, GLCM, GLSZM, RLM, formfactor, haralick)	mRMR method and the elastic network algorithm	Multivariable cox regression	No	Parameters independently associated with OS (P < 0.05)	Clinicopathological and radiomics features are independently associated with the OS of patients with primary liver cancer
Zhang et al[126], 2020	P	PR	OS after surgical resection	120 (HCC)	T2WI FS; DCE (AP, PVP, TP, and HBP)	S; 2D	AK software	350 (histogram, form factor, GLCM, GLRLM)	ICC, LASSO	LASSO Cox regression	Yes	C-index = 0.92	Radiomics + clinic-radiological predictors can efficiently aid in preoperative HCC prognosis prediction after surgical resection with respect to clinic-radiological model
Hectors et al[127], 2020	P	PR	6- and 12- week response to 90 yr	24 (HCC)	DCE-MRI, IVIM-DWI	M; 3D	Matlab	40 DCE MRI histogram parameters and 20 IVIM DWI histo-gram parameters	Stepwise feature selection	LR	No	AUC = 0.92	Diffusion and perfusion MRI can be combied to evaluate the response of HCC to radioembolization
Shi et al[128], 2020	P	PPF, MC	HCC GRADE, KI67+ HCC, CAPSULE FORMATION+	52 (HCC)	IVIM	M; 3D	ImageJ, Mazda	15 (histogram)	t-test	LR	No	AUC = 0.92 (grading), 0.86 (Ki67+) and 0.84 (capsule formation)	Multiple prognostic factors can be accurately predicted with assistance of histogram metrics sourced from a single IVIM scan
Feng et al[129], 2020	R	D, MC	DD	104 (HCC)	Gd-EOB-DTPA-enhanced MRI and T2WI	M, 3D	Mazda	262 (Histogram, GLCOM, GLRLM, WAVELET TRANSFORM)	PCA, LDA, NDA, RDA	ROC	No	AUC = 0.879	Texture analysis of Gd-EOB-DTPA-enhanced MRI and T2WI was valuable and might be a promising method in identifying the HCC grade
Nebbia et al[130], 2020	R	PPF	MVI	99 (HCC)	T2WI; DCE (AP and PP); DWI	M; 3D	Pyradiomics	100 (shape, first-order, texture -GLCM, GLDM, GLSZM-)	LASSO	SVM; DT; KNN, NB	No	AUC = 0.867	Information from mpMRI sequences is complementary in identifying MVI
Schobert et al[131], 2020	R	PR	Response to DEB-TACE, PFS	46 (HCC)	DCE (HAP, PVP, and DP)	M; 3D	Pyradiomics	14 (shape, first-order)	Univariate analysis, stepwise forward selection	LinearRegression; Cox regression; Kaplan–Meier analysis	No	High NLR and PLR correlated with non-spherical tumor growth (P = 0.001 and P < 0.001)	This study establishes the prognostic value of quantitative inflammatory biomarkers associated with aggressive nonspherical tumor growth and predictive of poorer tumor response and shorter PFS after DEB-TACE
Sun et al[132], 2020	R	PR	Early progression of unresectable HCC after TACE	84 (HCC)	T2WI; DWI; ADC	M; 3D	Pyradiomics	1597 (first-order, shape, texture -GLCM, GLRLM, GLSZM, NGTDM, GLDM-)	Variance threshold, Pearson's correlation, LASSO	LR	Yes	AUC = 0.800	mpMRI-based radiomic model predicts the outcome of TACE therapy for unresectable HCC outperforms monomodality radiomic models
Wilson et al[133], 2020	R	PPF, PR	MVI, OS, DFS after surgery	38 (HCC)	T2WI; in-phase and out-of-phase sequences; DCE (HAP, and PVP)	M; 2D	TexRAD	7 (histogram)	NO	LR	No	AUC = 0.83	Tumor entropy and mean are both associated with MVI. Texture analysis on preoperative imaging correlates with microscopic features of HCC
Hectors et al[134], 2020	R	MC, PR	Immuno-oncological markers (CD3, CD68, CD31), recurrence at 12 m	48 (HCC)	DCE (Pre-T1WI, AP, PVP, LVP, and HBP); ADC	M; 2D	MATLAB	36 (Haralick, qualitative and quantitative)	NO	LR	No	AUC = 0.76–0.80	MRI radiomics features may serve as noninvasive predictors of HCC immuno-oncological characteristics and tumour recurrence
Wang et al[135], 2020	R	MC	CK19+ HCC	227 (HCC)	DWI; ADC; T2WI; DCE (Pre-T1WI, AP, PVP, DP, and HBP)	M; 3D	Pyradiomics	647 (shape, histogram, texture, wavelet)	ICC, LASSO	Logistic model; ROC	Yes	AUC = 0.95	The combined model based on a fusion radiomics signature derived from AP and HBP can be a reliable biomarker for CK19 status of HCC
Wang et al[136], 2020	R	PR	5 yr survival after curative hepatectomy	201 (HCC)	T1WI; T2WI; DWI; ADC; DCE (AP, PVP, and EP)	S; 3D	Precision Medicine Open Platform	3144 (histogram, texture, wavelet, statistical)	Gini index	Random Forest	Yes	AUC = 0.9804 and 0.7578 in the TS and VS	This radiomics model is a valid method to predict 5-year survival in HCC patients
Song et al[137], 2020	R	PR	RFS after c-TACE	184 (HCC)	DCE (AP, and PVP)	S; 3D	AK software	396 (histogram, GLCM, GRLM, GLSZM)	ICC, LASSO	LASSO Cox regression	Yes	C-index = 0.802	The combined model is more valuable than the clinical-radiological model or radiomics model alone for evaluating the RFS of HCC patients after c-TACE
Zhang et al[138], 2019	R	PR	ER (1 yr after hepatectomy)	100 (HCC)	DCE (AP, PVP, and DP)	S; 3D	Omni Kinetic	6 (skewness, kurtosis, uniformity, energy, entropy, and correlation)	NO	LR	No	AUC = 0.867	Texture analysis based on preoperative MRI are potential quantitative predictors of ER in HCC patients after hepatectomy
Huang al[139], 2019	R	D, PR	DD (HCC vs DPHCC), DFS, OS after surgery	100 (HCC)	DCE (AP, PVP, DP, and HBP)	M; 3D	Huiying Medical Technology	1029 (First-order, shape, texture -GLCM, GLRLM, GLSZM-)	LASSO	Multi-layer perceptron; SVM; LR; K-nearestneighbor; ROC	No	Accuracy of LR in PVP (0.77), DP (0.798), HBP (0.756) and of multi-layer perceptron in PVP (0.798)	The radiomics features extracted from DCE-MRI can be used to diagnose preoperative DPHCC
Ye et al[140], 2019	P	MC	Ki67 expression	89 (HCC)	T2WI FS; DCE (Pre-T1WI, AP, PVP, TP, and HBP)	M; 3D	AK software	396 (histogram, texture, GLCM, GLRLM)	LASSO	LR	No	C-index = 0.936	The combination of DCE-MRI texture signature and clinical factors demonstrated the potential to preoperatively predict Ki-67 status of HCC after curative resection
Zhang et al[141] 2019	R	PPF	MVI	267 (HCC)	T2WI FS; in-phase and out-of-phase sequences; T1WI; DWI; DCE (AP, PVP, and EP)	M; 3D	MATLAB	484 (intensity, texture, wavelet)	mRMR	LR	Yes	AUC = 0.784 and 0.820 in TS and VS	The radiomics nomogram can serve as a visual predictive tool for MVI in HCC and outperformed clinico-radiological model
Chen et al[142], 2020	R	MC	CK19+, EpCAM	115 (HCC)	T2WI, pre-T1WI, DCE (AP, PVP, HBP), ADC	M; 3D	AK software	23 (histogram)	Univariate analysis	LR	No	Accuracy = 0.86, C-index = 0.94	Noninvasive prediction of HCCs with progenitor phenotype can be achieved with high accuracy by integrated interpretation of biochemical and radiological information
Xu et al[143], 2019	R	PPF	HCC GRADE	51 (HCC)	ADC	M; 3D	SPSS	27 (histogram)	NO	NO	No	ρ = −0.397 for ADC 25th percentile; AUC = 0.76 for ADC min	The 25th percentile ADC showed a stronger correlation with the histological grade of HCC than other ADC parameters, and the minimum ADC value might be an optimal metric for determining poor and fair diferentiations of HCC in DWI
Li et al[144], 2019	R	MC	Ki67 expression	83 (HCC)	DCE (HAP, PVP, EP, and HBP); T2WI FS	M; 3D	MaZda	30 (histogram, GLCM, GLRLM, absolute gradient, the autoregressive model, wavelet transform)	Fisher coefficient, MI, POE + ACC, correlation	ROC (accuracy)	No	Lowest misclassification rates: PCA-PVP = 40.96%; LDA-PVP = 9.64%; NDA-AP = 6.02%.	Texture analysis of HBP, arterial phase, and portal venous phase are helpful for predicting Ki67 expression
Oyama et al[145], 2019	R	D	DD (HCC, MT, HH)	93 (50 HCCs, 50 MTs, 50 HHs)	T1WI	M; 3D	MATLAB	43 (GLCM, GLRLM, GLSZM, NGTDM)	correlation	LDA	No	Accuracy = 92% (texture analysis) and 85% (persistence imges analyses)	Texture analysis or topological data analysis support the classifcation of HCC, MT, and HH with considerable accuracy, solely based on non-contrast-enhanced T1WI 3D
Wang et al[146], 2019	R	MC	CK19+ HCC	48 (HCC)	T2WI FS; in-phase and out-of-phase sequences; DCE (AP, PVP, DP); DWI (b values 0 and 500 s/mm²); ADC	M; 2D	In-house software	2415 (intensity, gradient, Gabor wavelet, local binary pattern histogram Fourier, GLCM, GLGCM)	LDA (AUC)	LR	No	AUC = 0.765	The StdSeparation 3D texture character may be a reliable imaging biomarker which can improve the diagnostic performance.
Zhu et al[147], 2019	R	PPF	MVI	142 (HCC)	DCE (AP, PVP)	M; 3D	Omni-kinetics software	58 (histogram, GLCM, Haralick, GRLM)	Kruskal-Wallis, univariate LR, Pearson's correlation	LR	Yes	AUC = 0.81	The combined model of arterial phase radiomic features with clinical-radiological features could improve MVI prediction ability
Zhang et al[148], 2019	P	PR	ER (1 yr after surgical resection)	155 (HCC)	T2WI FS, DCE (AP, PVP, TP, and HBP)	M; 3D	AK software	385 (histogram, texture, GLCM, GLRLM)	LASSO	LR; ROC	Yes	AUC = 0.844	The radiomics nomogram integrating the radiomics score with clinical-radiological risk factors showed better discriminative performance than the clinical-radiological nomogram
Gordic et al[149], 2019	R	PR	CR, PR, SD	22 (HCC)	volumetric ADC	M; 3D	MATLAB	7 (histogram)	Wald test	LR	No	AUC = 0.91	Diffusion histogram parameters obtained at 6w and early changes in ADC from baseline are predictive of subsequent response of HCCs treated with RE
Jansen et al[150], 2019	R	D	DD (adenomas, cysts, hemangiomas, HCC, metastases)	211 (40 adenomas, 29 cysts, 56 hemangiomas, 30 HCC, 56 metastases)	DCE-MRI, T2WI	M; 2D	NS	164 (contrast curve, histogram, and GLCM texture)	ANOVA F-SCORE	Randomized tree classifier	No	Accuracy = 0.77	The proposed classification system using features derived from clinical DCE-MR and T2WI, with additional risk factors is able to differentiate five common types of lesions and is a step forward to a clinically useful aid for focal liver lesion diagnosis
Ma et al[151], 2019	R	PR	Post RFA progression	64 (HCC)	ADC	M; 3D	Volume View	8 (histogram)	NO	Cox-regression	No	C-index = 0.62	Pre-RFA ADC histogram analysis might serve as a useful biomarker for predicting tumor progression and survival in patients with HCC treated with RFA
Wu et al[152], 2019	R	D	DD (HCC, HH)	369 (222 HCCs, 224 HHs)	In-phase and out-of-phase sequences; T2WI; DWI	M; 3D	PyRadiomics	1029 (shape, first-order, texture -GLCM, GLRLM, GLSZM-, exponential, square, square root, logarithm, and wavelet)	Variance threshold, select k best, LASSO	Decision tree; random forest; K nearest neighbours; LR; ROC	Yes	AUC = 0.86 and 0.89 in TS and VS	mpMRI radiomics signature is an adjunct tool to distinguish HCC and HH, outperformed a less experienced radiologist, and is nearly equal to an experienced radiologist
Kim et al[153], 2019	R	PR	ER (< = 2 yr), LR (> 2 yr) after curative resection	167 (HCC)	DCE (AP, PP, HBP, AP-PP, AP-HBP, PP-HBP, and AP-PP-HBP)	S; 3D	PyRadiomics	1301 (first-order, shape, texture -GLCM, GLRLM, GLSZM, NGTDM, GLDM-, LoG, wavelet)	RF minimal depth algorithm	random survival forest	Yes	C-index = 0.716	The clinicopathologic-radiomic model showed best performances, suggesting the importance of including clinicopathologic information in the radiomic analysis of HCC
Lewis et al[154], 2019	R	D	DD (HCC, ICC, HCC-ICC)	63 (36 HCC; 17 ICC; 12 HCC-ICC)	ADC	M; 3D	MATLAB	11 (histogram)	Wald criteria	Binary LR and AUROC	No	AUC = 0.9	The combination of quantitative ADC histogram parameters and LI-RADS categorization yielded the best prediction accuracy for distinction of HCC vs ICC and combined HCC-ICC
Chen et al[155], 2019	R	MC	Immunoscore (CD3+ and CD8+)	207 (HCC)	HBP	M; 3D	AK software	1044 (histogram, texture, factor parameters, GLCM, GLRLM, GLSZM)	Recursive elimination	LR	Yes	AUC = 0.92	The combined MRI-radiomics-based clinical nomogram is effective in predicting immunoscore in HCC
Feng et al[156], 2019	R	PPF	MVI	160 (HCC)	HBP	M; 3D	AK software	1044 (histogram, texture, wavelet transformed, filter transformed texture)	LASSO	LR	Yes	AUC = 0.85 and 0.83 in TS and VS	A combined intratumoural and peritumoural radiomics model based on DCE-MRI is able to pre-operatively predict MVI in primary HCC patients
Wu et al[157], 2019	R	PPF	HCC grade	170 (HCC)	T1WI; T2WI FS	M; 3D	MATLAB	656 (histogram, shape, GLCM, wavelet)	LASSO	LR	Yes	AUC = 0.8	The combination of the radiomics signatures with clinical factors may be helpful for the preoperative prediction of HCC grade
Yang et al[158], 2019	R	PPF	MVI	208 (HCC)	T2WI FS; DWI; DCE (AP, PVP, DP, and HBP)	M; 3D	MATLAB	647 (shape, intensity, textur-GLCM, GLRLM, GLZLM, NGLDS-)	LASSO, AIC	LR	Yes	AUC = 0.94 and 0.86	The nomogram incorporating clinicoradiological risk factors and radiomic features derived from HBP images achieved satisfactory preoperative prediction of the individualized risk of MVI in HCC patients
Stocker et al[159], 2018	R	D	DD (HCC vs FNH vs HA)	108 (55 HCC, 24 HA, 29 FNH)	T1WI FS; T2WI; DCE (AP, PVP, and HBP)	M; 2D	MATLAB	19 (histogram, GLCM, GLRLM)	LR	LR; ROC	No	AUC = 0.92	2D-TA of MR images may help to distinguish HCC from benign hepatocellular tumors in the non-cirrhotic liver, with most promising results were found in TA features in the AP images
Ahn et al[160], 2019	R	PR	ER (1y after surgical resection)	179 (HCC)	HBP	M; 3D	In-house software program	13 (histogram, GLCM)	Univariate analysis	LR	No	AUC = 0.83	When added texture variables to MRI findings, the diagnostic performance for predicting early recurrence is improved
Hui et al[161], 2018	R	PR	ER (1yr), LNR (late or no recurrence) after surgery	50 (HCC)	T2WI; DCE (AP, PVP and EP)	M; 2D	MaZda	290 (histogram, texture, autoregressive model, GRLM, GLCM, wavelet)	PRTools	ROC	No	Accuracy 78%-84%	Texture analysis of preoperative MRI has the potential to predict ER of HCC with up to 84% accuracy using an appropriate, single texture analysis parameter
Zou et al[162], 2019	R	D	DD (IMCC and HCC)	33 IMCC, 98 HCC	volumetric ADC, DCE-MRI	M; 3D	SPSS	9 (histogram)	NO	ROC	No	AUC = 0.79	Volumetric ADC histogram analysis provides additional value to dynamic enhanced MRI in differentiating IMCC from HCC
Li et al[163], 2018	P	PPF	MVI	41 (HCC)	IVIM-DWI	M; 3D	MATLAB	10 (histogram)	Univariate analysis	ROC	No	AUC = 0.87	Histogram analysis of IVIM based on whole tumor volume can be useful for predicting MVI. The 5th percentile of D was most useful value to predict MVI of HCC
Wu et al[164], 2019	P	PR	TTP after TACE	55 (HCC)	IVIM-DWI	S; 3D	MR OncoTreat	8 histogram parameters	NO	Cox-regression	No	AUC = 0.82	Pre-TACE kurtosis of ADCtotal is the best independent predictor for TTP
Li et al[165], 2017	R	D	DD (HH vs HM vs HCC)	162 (55 HH, 67 HM, 40 HCC)	SPAIR T2WI	M; 2D	MATLAB	233 (histogram, GLCM, GLGCM, GLRLM, GWTF, ISZM)	CCC, DR, R2	ROC, KNN, BP-ANN, SVM, LR	Yes	Misclassification rates: 11.7% (HH vs HM), 9.6% (HM vs HCC) and 9.7% (HH vs HCC)	Texture features of T2WI SPAIR can classify HH, HM and HCC
Moriya et al[166], 2017	R	D	HCC grade	53 (HCC)	DWI, ADC	A; 3D	SPSS	11 (First Level)	ANOVA	ROC	No	sensitivity: 100%, specificity: 54%	Minimum ADC was most useful to differentiate poorly differentiated HCC in 3D analysis of ADC histograms

ST: Study type; R: Retrospective; P: Prospective; CP: Clinical purpose; D: Diagnosis; PPF: Prediction of pathological findings; PR: Prognosis; MC: Molecular characterization; NP: Number of patients; Seg: Segmentation; FS: Feature selection; CM: Classification method; DD: Differential diagnosis; cCC-HCC: Combined hepatocellular cholangiocarcinoma; HCC: Hepatocellular carcinoma; CC: Cholangiocarcinoma; MVI: Microvascular invasion; AIR: Aggressive intrasegmental recurrence; RFA: Radiofrequency ablation; VECT: Vessels encapsulating tumor clusters; PFS: Progression-free survival; TACE: Transcatheter arterial chemoembolization; CK19: Cytokeratin19; RFS: Recurrence-free survival; FNH: Focal nodular hyperplasia; GOLM1: Golgi membrane protein 1; SETD7: SET domain containing 7; RND1: Rho family GTPase 1; GPC3: Glypican-3; MVD: Microvessel density; MTM-HCC: Macrotrabecular-massive hepatocellular carcinoma; ER: Early recurrence; HH: Hepatic hemangioma; HC: Hepatic cysts; OS: Overall survival; TFS: Transplant-free survival; HMRC: Hepatic metastasis of rectal cancer; CK7: Cytokeratin7; DEB-TACE: Drug-eluting bead-transcatheter arterial chemoembolization; DFS: Disease-free survival; DPHCC: Dual-phenotype HCC; EpCAM: Epithelial Cell Adhesion Molecule; MT: Metastatic tumor; CR: Complete response; PR: Partial response; SD: Stable disease; LR: Logistic regression; LRec: Late Recurrence; ICC: Intrahepatic cholangiocarcinoma; HA: Hepatic adenoma; LNR: Late regional recurrence; IMCC: Mass-forming cholangiocarcinoma; TTP: Time to progression; HM: Hepatic metastases; DCE: Dynamic contrast-enhanced; ART: Arterial phase; PVP: Portal venous phase; DP: Delayed phase; T1WI: T1-weighted imaging; AP: Arterial phase; HBP: Hepatobiliary phase; HAP: Hepatic arterial phase; SPP: Substantial period phase; T2WI: T2-weighted imaging; DWI: Diffusion-weighted imaging; EP: Equilibrium phase; LAP: Late arterial phase; TP: Transitional phase; PP: Portal phase; FS: Fat saturation; ADC: Apparent diffusion coefficient; DCE-MRI: DCE-Magnetic Resonance Imaging; IVIM: Intravoxel incoherent motion; SWI: Susceptibility weighted imaging; LVP: Late venous phase; SPAIR T2WI: Spectral attenuated inversion-recovery T2WI; M: Manually; S: Semi-automatic; A: Automatic; GLCM: Gray-level co-occurrence matrix; GLSZM: Grey Level Size Zone Matrix; GLRLM: Gray-level run-length; GLDM: Gray level dependence matrix; NGTDM: Neighboring gray tone difference matrix; CNN: Convolutional neural network; LBP: Local binary patterns; FOS: First-order statistics; NGLDS: Neighborhood gray-level difference statistics; RLM: Run-length matrix; GWTF: Gabor wavelet transform; ISZM: Intensity-size-zone matrix; MI: Mutual information; LASSO: Least absolute shrinkage and selection operator; mRMR: Minimum redundancy maximum relevance; RF: random forests; SVM-RFE: Support vector machine-recursive feature elimination; ICC: Intra-class correlation coefficient; PCA: Principal component analysis; RandomForestSRC: Random Forests for Survival, Regression, and Classification; LR: Logistic regression; POE + ACC: Classification error probability combined with average correlation coefficients; ROC: Receiver operating characteristic; LDA: Linesar discriminant analysis; AUC: Area under the curve; AIC: Akaike information criteria; CCC: Concordance correlation coefficient; DR: Dynamic range; ANN: Artificial neural network; GBDT: Gradient Boosting Tree; KNN: K-nearest Neighbours; XGBoost: Extreme gradient boosting; DT: Decision trees; DL: Deep learning; FDA: Fisher discriminant analysis; AUROC: Area under the receiver operating characteristic; BP-ANN: Back propagation artificial neural network; TS: Training sets; VS: Validation sets; ICG: Indocyanine green retention rate; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; CAD: Computer-aided diagnostic; TR: Transcatheter arterial chemoembolization response; SITET: Single-input two-compartment extended Tofts; DITET: Dual-input two-compartment extended Tofts; c-TACE: Conventional-transcatheter arterial chemoembolization; TA: Texture analysis; RE: Radioembolization.