Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe obesity

Table 2 Pathway analysis for miRNA associated with multiple histological features of non-alcoholic fatty liver disease in teen-longitudinal assessment of bariatric surgery participants

Disease and functions	miRNA
Apoptosis of tumor cell lines	miR-122-5p, miR-193b-5p, miR-199b-5p, miR-323-3p
Migration of cells	miR-122-5p, miR-193a-5p, miR-199b-5p
Apoptosis of myeloma cell lines	miR-122-5p, miR-193a-5p
Dedifferentiated liposarcoma	miR-193a-5p, miR-199b-5p
Production of hepatitis C virus	miR-122-5p
Decay of RNA	miR-122-5p
Metastatic hepatocellular carcinoma	miR-122-5p
Replication of viral replicon	miR-122-5p
Invasion of hepatoma cell lines	miR-122-5p
Chemosensitivity of squamous cell carcinoma cell lines	miR-193a-5p
Epithelial-mesenchymal transition of adenocarcinoma cell lines	miR-193a-5p
Migration of adenocarcinoma cell lines	miR-193a-5p
Congenital adrenal hyperplasia	miR-199b-5p
Chronic hepatitis B	miR-199b-5p
Early-stage invasive cervical squamous cell carcinoma	miR-199b-5p
Proliferation of myeloma cell lines	miR-199b-5p

A total of 16 miRNA were included as input for independent practice association. To ensure reliability and relevance of results, we specifically extracted pathways that were experimentally confirmed in human studies, considering only those with P < 0.05.