Efficacy and safety of low-dose tetracycline, amoxicillin quadruple therapy in Helicobacter pylori infection: A retrospective single center study

Table 2 Treatment times of patients and the eradication rates

	Eradication rate			P value
	500 mg bid (n = 73)	500 mg tid (n = 74)	750 mg bid (n = 71)
All	65, 89.0%	61, 82.4%	56, 78.9%	0.25
Primary therapy	54/60, 90.0%	37/42, 88.1%	14/16, 87.5%	0.85
1 prior therapy	8/8, 100%	22/27, 81.5%	27/39, 69.2%
≥ 2 prior therapies	3/5, 60.0%	2/5, 40.0%	15/16, 93.8%
Rescue therapy1	11/13, 84.6%	24/32, 75.0%	42/55 76.4%	0.89

¹Rescue therapy was defined as patients who had received eradication therapy once or more but failed.

P values were from two-sided comparisons of the differences between the three groups. 500 mg bid: Tetracycline twice daily; 500 mg tid: Tetracycline three times daily; 750 mg bid: Tetracycline twice daily.