Comparison of clinical characteristics and prognostic factors in two site-specific categories of ampullary cancer

Table 4 Univariate and multivariate Cox regression analysis of duodenal papilla cancer

Characteristics	Univariate		Multivariate
	HR (95%CI)	P value	HR (95%CI)	P value
Sex (male/female)	1.226 (0.698-2.154)	0.478
Age (≤ 60/> 60), year	0.461 (0.262-0.811)	0.007a	0.372 (0.189-0.733)	0.004a
BMI, kg/m2
< 18.5		Reference
18.5-24	0.693 (0.306-1.569)	0.380
> 24	0.375 (0.126-1.120)	0.079
Diabetes (yes/no)	3.832 (0.529-27.767)	0.184
Neutrophil count (≤ 2.815/> 2.815), × 109/L	1.751 (0.991-3.096)	0.054
Lymphocyte count (≤ 1.395/> 1.395), × 109/L	2.910 (1.486-5.698)	0.002a	2.446 (0.932-6.418)	0.069
Blood platelet count (≤ 196.5/> 196.5), × 109/L	1.556 (0.870-2.782)	0.136
Preoperative albumin (≤ 32.5/> 32.5), g/L	2.579 (1.431-4.647)	0.002a	2.266 (0.666-7.711)	0.191
ALT (≤ 114.5/> 114.5), U/L	0.633 (0.361-1.109)	0.110
AST (≤ 51.5 /> 51.5), U/L	0.575 (0.287-1.153)	0.119
Tbil (≤ 27.25/> 27.25), μmol/L	0.354 (0.166-0.755)	0.007a	0.634 (0.248-1.619)	0.341
NLR (≤ 3.21/> 3.21)	0.663 (0.376-1.171)	0.157
PLR (≤ 184.92/> 184.92)	0.539 (0.306-0.949)	0.032a	0.734 (0.334-1.614)	0.442
PNI (≤ 36.98/> 36.98)	2.333 (1.216-4.476)	0.011a	0.315 (0.072-1.379)	0.125
CA19-9 (≤ 143.9/> 143.9), U/mL	0.414 (0.235-0.731)	0.002a	0.808 (0.389-1.678)	0.567
ASA
I		Reference
II	0.540 (0.220-1.290)	0.160
III	0.630 (0.230-1.790)	0.380
T stage
T1		Reference
T2	1.740 (0.949-3.189)	0.073
T3	2.601 (0.610-11.088)	0.196
N stage
N0		Reference
N1	2.154 (1.128-4.113)	0.020a	0.800 (0.201-3.189)	0.752
N2	3.123 (0.942-10.354)	0.063	0.365 (0.038-3.554)	0.386
TNM stage
I	-	Reference
II	1.948 (1.001-3.790)	0.050	1.973 (0.598-6.516)	0.265
III	4.344 (1.856-10.165)	0.001a	3.247 (0.402-26.228)	0.269
Duration of surgery, min (≤ 351/> 351)	1.791 (0.982-3.266)	0.058
Intraoperative blood loss, mL (305 ≤/> 305)	0.802 (0.454-1.414)	0.445
Tumor size (≤ 2.35/> 2.35), cm	0.463 (0.263-0.816)	0.008a	0.436 (0.213-0.893)	0.023a
Number of positive lymph nodes (≤ 1/≥ 2)	0.446 (0.230-0.865)	0.017a	0.328 (0.141-0.767)	0.010a
Adjuvant therapy (yes/no)	0.253 (0.079-0.815)	0.021a	0.233 (0.068-0.797)	0.020a

^aP value < 0.05.

BMI: Body mass index; Tbil: Total bilirubin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; NLR: Neutrophil to lymphocyte ratio; PLR: Platelet to lymphocyte ratio; PNI: Prognostic nutritional index; ASA: American Society of Anesthesiologists.