Comparison of clinical characteristics and prognostic factors in two site-specific categories of ampullary cancer

doi:10.3748/wjg.v30.i39.4281

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Oct 21, 2024 (publication date) through Jan 19, 2025

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Oct 21, 2024; 30(39): 4281-4294
Published online Oct 21, 2024. doi: 10.3748/wjg.v30.i39.4281

Table 3 Univariate and multivariate Cox regression analysis of ampulla of Vater cancer

Characteristics	Univariate		Multivariate
Characteristics	HR (95%CI)	P value	HR (95%CI)	P value
Sex (male/female)	1.079 (0.600-1.938)	0.800
Age (≤ 60/> 60), year	0.877 (0.485-1.586)	0.664
BMI, kg/m²
< 18.5		Reference
18.5-24	1.256 (0.298-5.298)	0.756
> 24	1.876 (0.414-8.494)	0.414
Diabetes (yes/no)	1.048 (0.253-4.348)	0.949
Neutrophil count (≤ 5.39/> 5.39), × 10⁹/L	2.434 (0.961-6.168)	0.061
Lymphocyte count (≤ 1.21/> 1.21), × 10⁹/L	1.812 (1.006-3.262)	0.048^a	1.849 (0.969-3.529)	0.062
Blood platelet count (≤ 165/> 165), × 10⁹/L	2.083 (1.074-4.039)	0.030^a	1.791 (0.893-3.591)	0.101
Albumin (≤ 38.45/> 38.45), g/L	1.840 (1.015-3.336)	0.045^a	2.387 (1.247-4.569)	< 0.01^a
ALT (≤ 283/> 283), U/L	0.369 (0.114-1.192)	0.096
AST (≤ 277/> 277), U/L	0.437 (0.106-1.803)	0.252
Tbil (≤ 28.4/> 28.4), μmol/L	0.440 (0.205-0.945)	0.035^a	0.343 (0.143-0.825)	0.017^a
NLR (≤ 5.90/> 5.90)	0.181 (0.025-1.315)	0.091
PLR (≤ 186.6/> 186.6)	0.737 (0.408-1.332)	0.312
PNI (≤ 44.6/> 44.6)	0.664 (0.363-1.214)	0.183
CA19-9 (≤ 37.54/> 37.54), U/mL	1.258 (0.690-2.291)	0.454
ASA
I		Reference
II	0.536 (0.223-1.288)	0.163
III	0.633 (0.225-1.786)	0.388
T stage
T1		Reference
T2	1.641 (0.811-3.321)	0.168
T3	1.354 (0.392-4.679)	0.632
N stage
N0		Reference
N1	1.389 (0.642-3.005)	0.404
N2	1.524 (0.355-6.529)	0.571
TNM stage
I		Reference
II	1.142 (0.516-2.526)	0.743
III	2.413 (0.959-6.072)	0.061
Duration of surgery (≤ 368/> 368), min	0.853 (0.471-1.544)	0.599
Intraoperative blood loss (280 ≤ /> 280), mL	0.895 (0.464-1.726)	0.741
Tumor size (≤ 1.99/> 1.99), cm	0.475 (0.210-1.072)	0.073
Number of positive lymph nodes (≤ 1/≥ 2)	0.407 (0.208-0.796)	< 0.01^a	0.375 (0.189-0.745)	< 0.01^a
Adjuvant therapy (yes/no)	0.988 (0.475-2.053)	0.974

^aP < 0.05.

BMI: Body mass index; Tbil: Total bilirubin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; NLR: Neutrophil to lymphocyte ratio; PLR: Platelet to lymphocyte ratio; PNI: Prognostic nutritional index; ASA: American Society of Anesthesiologists; AVC: Ampulla of Vater cancer; DPC: Duodenal papilla cancer.

Citation: Zhang JZ, Zhang ZW, Guo XY, Zhu DS, Huang XR, Cai M, Guo T, Yu YH. Comparison of clinical characteristics and prognostic factors in two site-specific categories of ampullary cancer. World J Gastroenterol 2024; 30(39): 4281-4294
URL: https://www.wjgnet.com/1007-9327/full/v30/i39/4281.htm
DOI: https://dx.doi.org/10.3748/wjg.v30.i39.4281