Survival outcomes in early-onset oesophageal adenocarcinoma patients: A systematic review and meta-analyses

Table 1 Characteristics of studies investigating survival outcomes in early-onset oesophageal adenocarcinoma patients

Ref.	Publication year	Country	Study design	No. of cases	No. of cases < 50 (%)	Recruitment period	Age categories (years)	Stage	Follow-up (Y/N)	Specific survival outcome	Confounders considered
Boys et al[16]	2015	United States	Retrospective cohort	772	42 (5)	1990-2013	< 40, > 40	I-IV	Y	Median overall survival	Sex, race, staging, year of diagnosis
Kolb et al[17]	2020	United States	Population- based Register	114123	10271 (9)	2000-2017	< 50, 50-69, > 70	I-IV	Y	Median survival, HR of death	Treatment, staging, race
Codipilly et al[20]	2021	United States	Population based register	25813	2183 (8)	1975-2011	< 50, 50-69, > 70	I-IV	Y	Overall 5 year survival	Sex, race, staging, year of diagnosis
Xie et al[21]	2017	Sweden	Population- based cohort	5140	212 (4.1)	1961-2014	< 50, 50-59, 60-69, 70-79, > 80	Not recorded	Y	HR of death	Sex
Haiyu et al[22]	2019	United States	Population-based register	16474	Crude number not reported	1984-2013	20-44, 45-54, 55-64, 65-74, > 75	Not recorded	Y	5-year relative survival	Sex, Socio-economic status, race
Hashemi et al[23]	2009	United States	Consecutive case series	242	31 (12.8)	1994-2004	< 50, > 50	0-IV	N	Median survival	Sex, family history
Portale et al[24]	2004	United States	Consecutive case series	263	32 (12.1)	1992-2002	< 50, > 50	I-III	N	5-year survival rates
Sawas et al[14]	2019	United States	Single centre retrospective study	682	105 (15.4)	2009-2012	< 50, 51-70, > 70	I-IV	N	Mean survival, 5-year survival rates, HR of death	Sex, staging, intestinal metaplasia, Charlson comorbidity index
Strauss et al[25]	2020	United States	Single centre retrospective study	630	65 (10.3)	1991-2018	< 50, > 50	I-IV	Y	Overall survival, HR of death	Sex, race, pathology grade
van Nistelrooij et al[15]	2014	Netherlands	Population-based register	13331	1466 (10.9)	2000-2011	< 50, > 50	I-IV	Y	Median overall survival, 5-year overall survival	Sex, staging
Yang et al[26]	2016	United States	Population-based register	2601	94 (3.6)	1988-2011	< 45, 45-59, 60-74, > 75	I-III	Y	HR of death	Sex, race, lymph nodes examined

HR: Hazard ratio; Y: Yes; N: No.