Whole-volume histogram analysis of spectral-computed tomography iodine maps characterizes HER2 expression in gastric cancer

doi:10.3748/wjg.v30.i38.4211

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Oct 14, 2024 (publication date) through Nov 5, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 14, 2024; 30(38): 4211-4220
Published online Oct 14, 2024. doi: 10.3748/wjg.v30.i38.4211

Table 2 Comparison of spectral-computed tomography histogram parameters and HER-2 status in gastric cancer

Parameters	HER-2 positive (n = 21)	HER-2 negative (n = 80)	P value
Min	-2.000 (-5.518, 1.000)	-0.500 (-7.750, 5.000)	0.143
Max	37.000 (29.500, 40.622)	41.000 (36.000, 50.750)	0.018
Mean	17.429 (14.923, 19.341)	21.176 (17.529, 25.899)	0.001
Std	4.383 (3.663, 4.949)	5.037 (4.285, 5.883)	0.015
Variance	19.198 (13.417, 24.489)	25.366 (18.359, 34.604)	0.015
CV	0.269 ± 0.067	0.245 ± 0.071	0.163
Skewness	-0.051 (-0.246, 0.020)	-0.064 (-0.289, 0.182)	0.569
Kurtosis	0.282 (0.020, 0.683)	0.280 (0.037, 0.617)	0.861
Entropy	2.843 ± 0.256	3.012 ± 0.259	0.009
1^st percentile	6.037 (3.500, 9.000)	9.000 (6.000, 12.75)	0.007
5^th percentile	10.000 (7.000, 12.000)	12.500 (10.000, 16.750)	0.003
10^th percentile	11.000 (9.000, 13.500)	14.000 (12.000, 18.750)	0.003
25^th percentile	14.086 (12.000, 16.500)	17.000 (14.000, 21.750)	0.002
50^th percentile	18.000 (15.000, 19.500)	21.000 (18.000, 25.750)	0.001
75^th percentile	20.122 (18.000, 23.000)	24.000 (21.000, 30.500)	0.001
90^th percentile	24.000 (19.500, 26.000)	27.000 (24.000, 35.000)	0.001
95^th percentile	24.147 (21.000, 28.000)	29.000 (25.000, 37.750)	0.001
99^th percentile	28.171 (24.000, 30.500)	32.500 (28.000, 40.750)	0.001
Lesion volume	14.643 (4.214, 41.820)	9.930 (4.418, 21.191)	0.266

CV: Coefficient of variation.

Citation: Zhang WL, Sun J, Huang RF, Zeng Y, Chen S, Wang XP, Chen JH, Chen YB, Zhu CS, Ye ZS, Xiao YP. Whole-volume histogram analysis of spectral-computed tomography iodine maps characterizes HER2 expression in gastric cancer. World J Gastroenterol 2024; 30(38): 4211-4220
URL: https://www.wjgnet.com/1007-9327/full/v30/i38/4211.htm
DOI: https://dx.doi.org/10.3748/wjg.v30.i38.4211