Modulation of host N6-methyladenosine modification by gut microbiota in colorectal cancer

doi:10.3748/wjg.v30.i38.4175

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Oct 14, 2024; 30(38): 4175-4193
Published online Oct 14, 2024. doi: 10.3748/wjg.v30.i38.4175

Table 3 Relationships among N6-methyladenosine, colorectal cancer, and related mechanisms

m6A regulator	Upstream mechanism	Roles	Functions	Mechanism	Ref.
METTL3	Gut microbiota	Oncogene	Glycolysis, chemo-resistance↑	METTL3↑/LDHA↑	[100]
METTL3	Gut microbiota	Oncogene	Proliferation, migration, invasion↑	METTL3↑/m6A↑/YTHDF2↑/CRB3↓/Hippo↓	[55]
METTL3	Gut microbiota	Oncogene	Glycolysis, progression↑	METTL3↑/m6A/GLUT1↑/mTORC1 ↑	[101]
METTL3	Gut microbiota	Oncogene	Invasion, migration↑	METTL3↑/m6A/circ1662↑/YAP1↑/SMAD3↓	[102]
METTL3	F. nucleatum	Suppressor	Metastasis↑	METTL3↓/m6A↓/YTHDF2/KIF26B↑	[24]
METTL16	Gut microbiota	Oncogene	Glycolysis, progression↑	METTL14↑/IGF2BP1/SOGA1↑/PDK4↑	[83]
METTL14	ETBF	Suppressor	Proliferation↑	METTL14↓/m6A/miR-149-3p↓/PHF5A/KAT2A	[88]
METTL14	Gut microbiota	Suppressor	Proliferation, metastasis↑	METTL14↓/m6A↓/YTHDF2↓/lncRNA XIST↑	[103]
METTL14	Gut microbiota	Suppressor	Migration, invasion, metastasis↑	METTL14↓/m6A↓/YTHDF2/SOX4↑	[104]
ALKBH5	H3K27	Oncogene	Glycolysis, progression↓	ALKBH5↓/JMJD8↓/PKM2↓	[105]
ALKBH5		Oncogene	Proliferation, migration, invasion↑	ALKBH5↑/YTHDF2/RAB5A↑	[106]
ALKBH5		Suppressor	Radiosensitivity↑	ALKBH5↑/YTHDF2/circAFF2↑/Cullin-NEDD8↓	[107]
ALKBH5		Suppressor	Proliferation, migration, invasion↓	ALKBH5↑/PHF20↓	[91]
FTO		Oncogene	Chemo-resistance↑	FTO↑/YTHDF2/SIVA1↓	[92]
FTO	miR-96	Oncogene	Tumorigenesis, progression↑	AMPKα2↓/FTO↑/m6A↓/MYC↑	[93]
IGF2BP2	LINC00460	Oncogene	Proliferation, metastasis↑	IGF2BP2-DHX9↑/HMGA1↑	[108]
YTHDF1		Oncogene	Tumorigenesis, metastasis↑	YTHDF1↑/m6A/ARHGEF2↑	[109]
YTHDF2	miR-6125	Oncogene	Proliferation, growth↓	YTHDF2↓/m6A/GSK3β↑	[110]
HNRNPA2B1	MIR100HG	Oncogene	Chemo-resistance, metastasis↑	hnRNPA2B1↑/m6A/TCF7L2↑	[111]

m6A: N6-methyladenosine; F. nucleatum: Fusobacterium nucleatum.

Citation: Jiang TQ, Wang H, Cheng WX, Xie C. Modulation of host N6-methyladenosine modification by gut microbiota in colorectal cancer. World J Gastroenterol 2024; 30(38): 4175-4193
URL: https://www.wjgnet.com/1007-9327/full/v30/i38/4175.htm
DOI: https://dx.doi.org/10.3748/wjg.v30.i38.4175