Modulation of host N6-methyladenosine modification by gut microbiota in colorectal cancer

Table 2 The role of the gut microbiota in colorectal cancer

Gut microbiota	Roles	Functions	Mechanism	Ref.
Coriobacteriaceae	Promote	Tumorigenesis, progression↑	CPT1A-ERK axis	[68]
Clostridioides difficile	Promote	Tumorigenesis↑	Secrete toxin TcdB	[69]
F. nucleatum	Promote	Tumorigenesis, metastasis↑	modulate TME	[70,71]
ETBF	Promote	Progression↑	Suppress the immune responses	[72]
Escherichia coli	Promote	Proliferation, progression↑	Exert toxic effects on DNA	[73]
Enterococcus faecalis	Promote	Tumorigenesis, progression↑	Secrete metabolite biliverdin	[74]
Salmonella enterica	Promote	Tumorigenesis, proliferation↑	Express secretory protein AvrA	[75]
Streptococcus bovis/gallolyticus	Promote	Tumorigenesis, progression↑	Promote inflammatory response	[76]
Blautia producta	Suppress	Tumorigenesis, progression↓	Facilitate the immune surveillance	[77]
Lactobacillus acidophilus, Lactobacillus rhamnosus, and Lactobacillus casei	Suppress	Migration, invasion↓	Reduce abnormal crypt foci	[78]
Roseburia intestinalis	Suppress	Tumorigenesis, proliferation↓	Produce butyrate and induce CD8+ T cells	[79]
Akkermansia muciniphila	Suppress	Proliferation↓	Modulate CD8+ T cells	[80]

TME: Tumour microenvironment; F. nucleatum: Fusobacterium nucleatum.