Modulation of host N6-methyladenosine modification by gut microbiota in colorectal cancer

Table 1 Functions of N6-methyladenosine regulators

Types	Regulators	Functions	Ref.
	METTL3	Catalyses m6A modification	[30,31]
	METTL14	Provides structural support and recognizes target RNAs	[30,31]
	WTAP	Contributes to the orientation of MTC	[32,33]
	VIRMA/KIAA1429	Recruits m6A complexes to specialized RNA sites	[32,33]
m6A writers	ZC3H13	Bridges WTAP to Nito	[32,33]
	RBM15	Binds to the m6A complex and recruits to specialized RNA sites	[32,33]
	CBLL1/HAKAI	Contributes to the stabilization of MTC	[32,34]
	METTL16	Catalyses m6A modification	[35]
	FTO	Affects RNA splicing stabilization and deletes m6A modifications	[36]
m6A erasers	ALKBH5	Regulates RNA export and splicing, and deletes m6A modifications	[36]
	IGF2BPs	Enhances mRNA stability and translation	[37]
	YTHDC1	Mediates RNA splicing and export	[38]
	YTHDC2	Enhances target RNA translation and reduces RNA abundance	[39]
	YTHDF1	Enhances mRNA translation	[40]
	YTHDF2	Promotes mRNA degradation	[40]
m6A readers	YTHDF3	Synergizes with YTHDF1 and YTHDF2 to enhance translation and degradation	[40]
	ELF3	Enhances mRNA translation	[41]
	FMR1	Promotes mRNA degradation	[42]
	HNRNPs	Mediates mRNA splicing and translation	[43]
	HNRNPA2B1	Mediates mRNA splicing and miRNA processing	[44]
	ELAL1/HuR	Improve translation efficiency and stability of mRNA	[45]

m6A: N6-methyladenosine.