B-cell-specific signatures reveal novel immunophenotyping and therapeutic targets for hepatocellular carcinoma

Figure 4 Establishment of prognostic model of B-cell-related genes in hepatocellular carcinoma. A: Forest plot displays B-cell-related genes (BRGs) associated with hepatocellular carcinoma (HCC) prognosis, green indicates hazard ratio < 1, red indicates hazard ratio > 1; B: Heatmap illustrates the expression levels of BRGs associated with HCC prognosis in both HCC and paired adjacent non-tumor samples; C: Least absolute shrinkage and selection operator (LASSO) regression analysis cross-validation curve demonstrates the fitting effect of the model when incorporating different numbers of BRGs; D: LASSO coefficient path plot displays the lambda values when the model incorporates different numbers of BRGs; E: Survival analysis depicts the relationship between the expression levels of 11 BRGs included in the prognostic model and the prognosis of HCC patients; F: Single-cell analysis reveals the expression levels of the 11 BRGs included in the prognostic model within B cells of HCC. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001.