Pan-immune-inflammation value as a prognostic biomarker for colon cancer and its variation by primary tumor location

doi:10.3748/wjg.v30.i33.3823

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Sep 7, 2024 (publication date) through Dec 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Gastroenterol. Sep 7, 2024; 30(33): 3823-3836
Published online Sep 7, 2024. doi: 10.3748/wjg.v30.i33.3823

Table 3 Logistic multivariable analysis for high pan-immune-inflammation value ratio in left-sided colon cancer and right-sided colon cancer

Variables	LCC		RCC
Variables	aOR (95%CI)	P value	aOR (95%CI)	P value
Sex
Male	1 (Reference)	NA	1 (Reference)	NA
Female	1.36 (0.98-1.88)	0.062	1.49 (1.06-2.10)	0.022
Age
< 65	1 (Reference)	NA	1 (Reference)	NA
≥ 65	1.00 (0.73-1.38)	0.979	1.47 (1.04-2.07)	0.028
Tumor grade
G1-2	1 (Reference)	NA	1 (Reference)	NA
G3	1.45 (0.80-2.62)	0.217	2.05 (1.17-3.60)	0.013
T stage
T1-2	1 (Reference)	NA	1 (Reference)	NA
T3-4	1.52 (0.96-2.41)	0.076	2.07 (1.26-3.39)	0.004
N stage
N0	1 (Reference)	NA	1 (Reference)	NA
N1	0.97 (0.68-1.39)	0.874	1.29 (0.85-1.95)	0.237
N2	1.58 (0.93-2.67)	0.089	1.11 (0.63-1.945)	0.715
Tumor size
< 5 cm	1 (Reference)	NA	1 (Reference)	NA
≥ 5 cm	2.55 (1.85-3.51)	< 0.001	2.19 (1.55-3.10)	< 0.001
Vascular
No-invasion	1 (Reference)	NA	1 (Reference)	NA
Invasion	0.83 (0.56-1.25)	0.379	0.86 (0.56-1.30)	0.470
Perineural
No-invasion	1 (Reference)	NA	1 (Reference)	NA
Invasion	1.09 (0.69-1.72)	0.726	0.61 (0.36-1.02)	0.059
MMR
pMMR	1 (Reference)	NA	1 (Reference)	NA
dMMR	2.53 (1.53-4.18)	< 0.001	1.80 (1.18-2.76)	0.006
CEA
Low	1 (Reference)	NA	1 (Reference)	NA
High	1.94 (1.28-2.95)	0.002	1.20 (0.80-1.80)	0.376
CA19-9
Low	1 (Reference)	NA	1 (Reference)	NA
High	1.01 (0.62-1.62)	0.982	1.55 (0.87-2.74)	0.134

LCC: Left-sided colon cancer; RCC: Right-sided colon cancer; aOR: Adjusted odds ratio; CI: Confidence interval; PIV: Pan-immune-inflammation value; G1-2: Grades well and moderately differentiated; G3: Grade poorly differentiated; MMR: Mismatch repair; dMMR: Mismatch repair-deficient; pMMR: Mismatch repair-proficient; CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9; NA: Not available.

Citation: Wang QY, Zhong WT, Xiao Y, Lin GL, Lu JY, Xu L, Zhang GN, Du JF, Wu B. Pan-immune-inflammation value as a prognostic biomarker for colon cancer and its variation by primary tumor location. World J Gastroenterol 2024; 30(33): 3823-3836
URL: https://www.wjgnet.com/1007-9327/full/v30/i33/3823.htm
DOI: https://dx.doi.org/10.3748/wjg.v30.i33.3823