Ferroptosis in liver diseases: Fundamental mechanism and clinical implications

doi:10.3748/wjg.v30.i32.3730

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Aug 28, 2024 (publication date) through Dec 29, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 28, 2024; 30(32): 3730-3738
Published online Aug 28, 2024. doi: 10.3748/wjg.v30.i32.3730

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Figure 2 Strategies targeting ferroptosis for treatment of liver diseases. Ferroptosis has been associated with various liver diseases, including fatty liver disease, acute liver injury, chronic and acute liver failure, hepatitis, liver fibrosis/cirrhosis, and liver cancer. Compounds that inhibit or induce ferroptosis have the potential to impact the development of liver diseases. System Xc^-: Cystine/glutamate antiporter (Xc-) system; GPX4: Glutathione peroxidase 4; CoQ10: Coenzyme Q10; GCH1: Guanosine triphosphate cyclohydrolase 1; BH4: Tetrahydrobiopterin.

Citation: Lai MS, Yan XP, Branch DR, Loriamini M, Chen LM. Ferroptosis in liver diseases: Fundamental mechanism and clinical implications. World J Gastroenterol 2024; 30(32): 3730-3738
URL: https://www.wjgnet.com/1007-9327/full/v30/i32/3730.htm
DOI: https://dx.doi.org/10.3748/wjg.v30.i32.3730