Calcium/calcimimetic via calcium-sensing receptor ameliorates cholera toxin-induced secretory diarrhea in mice

Figure 2 Calcimimetic R568 reverses cholera toxin-induced diarrhea in wild type but not in intestine-specific calcium-sensing receptor knockouts. A: Experimental protocol; B: Representative images of R568 effect on fluid accumulation in the intestine of wild type mice; C: Summary of fluid accumulation in the intestine of wild type mice; D: Summary of fluid accumulation in the intestine of ^villinCre/Casr^flox/flox mice; E: Summary of fluid accumulation in the intestine of ^nestinCre/Casr^flox/flox mice. Mice were intragastrically gavaged with cholera toxin or vehicle while receiving R568 or vehicle intraperitoneally. Three and half-hours later, animals were killed, intestines removed, and fluid quantitated. Shown are means ± standard errors. ^aP < 0.05, ^bP < 0.01 vs without R568. CTX: Cholera toxin.