SLC6A14 promotes ulcerative colitis progression by facilitating NLRP3 inflammasome-mediated pyroptosis

Figure 7 SLC6A14 reduces pyroptosis induced by NLRP3 activation in ulcerative colitis mouse models. A: Measurement of colon length; B: Assessment of body weight changes; C: Disease-activity index; D: Histology (magnification 200 ×, scale bar = 100 μm); E and F: Western blot analysis of SLC6A14; G: Effects of SLC6A14 on IL-1β and IL-18 production in the ulcerative colitis mouse model, as measured by enzyme-linked immunosorbent assay; H: Western blot analysis of the levels of pyroptosis-associated proteins. The data are means ± SD. ^aP < 0.01 vs controls, ^bP < 0.01 vs DSS+LV-sh-CTRL. DSS: Dextran sulfate sodium.