SLC6A14 promotes ulcerative colitis progression by facilitating NLRP3 inflammasome-mediated pyroptosis

Figure 6 NLRP3 overexpression reverses the inhibitory effect of SLC6A14 knockdown on lipopolysaccharide-induced FHC cell pyroptosis. A: Effects of NLRP3 overexpression on IL-1β and IL-18 production facilitated by SLC6A14 in lipopolysaccharide (LPS)-treated intestinal epithelial cells (IECs), as shown by enzyme-linked immunosorbent assay; B: Western analysis of the effects of NLRP3 overexpression on pyroptosis-associated protein levels mediated by SLC6A14 in IECs after LPS treatment. ^aP < 0.01 vs controls; ^bP < 0.01 vs LPS; ^cP < 0.01 vs LPS+sh-SLC6A14. LPS: Lipopolysaccharide; OE: Overexpression.