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©The Author(s) 2024.
World J Gastroenterol. Jan 21, 2024; 30(3): 225-237
Published online Jan 21, 2024. doi: 10.3748/wjg.v30.i3.225
Published online Jan 21, 2024. doi: 10.3748/wjg.v30.i3.225
Table 2 Microbial alterations in Parkinson’s disease-related constipation after microbial treatments
Microbial treatments | Study design | Participant | Duration | Microbial alterations | Results | Ref. | |
Increased | Decreased | ||||||
Probiotics | Randomized controlled clinical trial | 46 | 12 wk | g_Christensenella_sp._Marseille-P2437 | g_Eubacterium_oxidoreducens_group, g_Eubacterium_hallii_group, s_Odoribacter_sp._N54.MGS-14 and Prevotellaceae | The probiotics group increased the average number of complete bowel movements per week as compared to the control group. The improvement rate of constipation in the probiotics group was significantly higher than that in the control group | [18] |
FMT | Case report | 1 | 3 d | Firmicutes | Proteobacteria, Bacteroidetes | After FMT, patients successfully defecated within 5 min and maintained daily unobstructed defecation until the end of follow-up | [14] |
FMT | A prospective, single-center study | 11 | 1 d | Blautia, Prevotella | Bacteroidetes | The PAC-QOL and Wexner constipation scores both decreased significantly | [129] |
- Citation: Yuan XY, Chen YS, Liu Z. Relationship among Parkinson’s disease, constipation, microbes, and microbiological therapy. World J Gastroenterol 2024; 30(3): 225-237
- URL: https://www.wjgnet.com/1007-9327/full/v30/i3/225.htm
- DOI: https://dx.doi.org/10.3748/wjg.v30.i3.225