Review
Copyright ©The Author(s) 2024.
World J Gastroenterol. Jan 21, 2024; 30(3): 225-237
Published online Jan 21, 2024. doi: 10.3748/wjg.v30.i3.225
Table 2 Microbial alterations in Parkinson’s disease-related constipation after microbial treatments
Microbial treatments
Study design
Participant
Duration
Microbial alterations
Results
Ref.
Increased
Decreased
ProbioticsRandomized controlled clinical trial4612 wkg_Christensenella_sp._Marseille-P2437g_Eubacterium_oxidoreducens_group, g_Eubacterium_hallii_group, s_Odoribacter_sp._N54.MGS-14 and PrevotellaceaeThe probiotics group increased the average number of complete bowel movements per week as compared to the control group. The improvement rate of constipation in the probiotics group was significantly higher than that in the control group[18]
FMTCase report13 dFirmicutesProteobacteria, BacteroidetesAfter FMT, patients successfully defecated within 5 min and maintained daily unobstructed defecation until the end of follow-up[14]
FMTA prospective, single-center study111 dBlautia, PrevotellaBacteroidetesThe PAC-QOL and Wexner constipation scores both decreased significantly[129]