Leech Poecilobdella manillensis protein extract ameliorated hyperuricemia by restoring gut microbiota dysregulation and affecting serum metabolites

Figure 5 Effect of leech Poecilobdella manillensis total protein extract on vital microbial genus. A: The absolute abundance of vital microbial genera in all groups, assessed through the Kruskal-Wallis ANOVA; B and C: Significant differences between each two groups at the genus level of gut microbiota, determined by DESeq2 method [B: normal control group vs hyperuricemia model group (HUA); C: HUA vs leech Poecilobdella manillensis total protein extract treatment group; n = 6 for each group]. Statistical significance is indicated as follows: ^aP < 0.05 vs hyperuricemia model group (HUA); ^bP < 0.01 vs HUA; ^cP < 0.001 vs HUA; ^dP < 0.05 vs normal control group (CON); ^eP < 0.01 vs CON. CON: Normal control group; HUA: Hyperuricemia model group; LTP: Leech Poecilobdella manillensis total protein extract treatment group.