Diagnostic delay in inflammatory bowel diseases in a German population

Table 2 Univariate analysis

Parameter		Patient waiting time		Physician diagnostic time
		HR	P value	HR	P value
Sex, female vs male	CD	1.235	0.089	0.852	0.222
	UC	0.954	0.714	0.897	0.407
Age, ≤ 40 vs > 40 yr	CD	1.071	0.654	1.176	0.329
	UC	1.407	0.031	1.109	0.508
Year of diagnosis, ≤ 2000 vs > 2000	CD	1.081	0.520	0.975	0.846
	UC	0.947	0.666	0.976	0.856
Predominant symptom
Diarrhea, yes vs no	CD	0.826	0.116	1.484	0.003
	UC	1.141	0.305	1.065	0.640
Constipation, yes vs no	CD	2.045	0.440	1.835	0.517
	UC	1.011	0.991	0.882	0.893
Abdominal pain, yes vs no	CD	1.307	0.038	0.834	0.191
	UC	1.096	0.701	0.708	0.167
Heartburn, yes vs no	CD	0.975	0.979	0.826	0.844
Bloating, yes vs no	UC	0.218	0.010	0.789	0.664
Blood in stool, yes vs no	CD	0.609	0.069	1.272	0.419
	UC	1.014	0.916	0.999	0.993
Nausea/vomiting, yes vs no	CD	1.216	0.520	0.675	0.233
Skin, yes vs no	CD	1.164	0.872	5.178	0.044
	UC	0.295	0.138	3.637	0.108
Joint pain, yes vs no	CD	0.844	0.703	0.323	0.039
Fistula, yes vs no	CD	2.450	0.032	0.656	0.334
Weight loss, yes vs no	CD	0.387	0.236	5.178	0.044
Fever, yes vs no	CD	0.387	0.236	0.620	0.619
	UC	6.191	0.026	1.207	0.838
Fatigue, yes vs no	CD	1.482	0.335	1.452	0.390
	UC	1.652	0.225	1.937	0.101
Symptoms
Diarrhea, yes vs no	CD	0.590	< 0.001	0.947	0.732
	UC	1.331	0.068	1.028	0.867
Constipation, yes vs no	CD	1.103	0.644	0.747	0.209
	UC	1.031	0.921	0.808	0.513
Abdominal pain, yes vs no	CD	0.988	0.934	0.963	0.812
	UC	1.018	0.889	0.952	0.708
Heartburn, yes vs no	CD	0.988	0.947	0.735	0.110
	UC	0.697	0.140	1.014	0.955
Bloating, yes vs no	CD	0.827	0.150	0.842	0.235
	UC	0.814	0.132	0.960	0.770
Blood in stool, yes vs no	CD	0.932	0.572	0.889	0.393
	UC	0.970	0.856	0.913	0.586
Nausea/vomiting, yes vs no	CD	1.264	0.075	1.082	0.574
	UC	1.210	0.334	0.966	0.864
Skin, yes vs no	CD	0.801	0.261	0.628	0.036
	UC	0.663	0.157	0.947	0.859
Joint pain, yes vs no	CD	0.882	0.403	0.733	0.066
	UC	0.780	0.309	0.836	0.478
Fistula, yes vs no	CD	1.280	0.231	0.937	0.770
	UC	0.694	0.421	0.766	0.574
Weight loss, yes vs no	CD	1.019	0.875	0.900	0.416
	UC	1.400	0.016	0.893	0.429
Fever, yes vs no	CD	1.196	0.239	1.142	0.420
	UC	1.381	0.150	1.654	0.026
Fatigue, yes vs no	CD	1.094	0.457	0.959	0.746
	UC	0.961	0.757	0.767	0.045
EIM, yes vs no	CD	0.902	0.450	0.784	0.104
	UC	0.745	0.129	0.913	0.651
Location
Upper GI, yes vs no	CD	1.198	0.400	1.256	0.323
	UC	0.813	0.748	0.668	0.545
Small bowel, yes vs no	CD	0.910	0.461	0.929	0.594
	UC	1.007	0.976	0.818	0.411
Terminal ileum, yes vs no	CD	0.964	0.778	1.183	0.237
	UC	0.849	0.432	1.087	0.700
Colon, yes vs no	CD	1.135	0.292	0.927	0.565
	UC	1.014	0.924	1.012	0.934
Rectum, yes vs no	CD	1.075	0.616	1.043	0.791
	UC	0.864	0.251	0.907	0.457
Disease severity, strong vs mild	CD	1.359	0.023	1.240	0.154
	UC	1.098	0.469	1.247	0.096
Diagnosis made in hospital, yes vs no	CD	0.915	0.464	0.992	0.952
	UC	1.314	0.039	1.013	0.923
Diagnosis made by gastroscopy, yes vs no	CD	1.059	0.891	2.857	0.011
	UC	1.520	0.644	0.804	0.815
Family history, positive vs negative	CD	1.587	0.005	1.073	0.697
	UC	0.767	0.120	0.708	0.053
Medication, strong vs mild	CD	1.067	0.647	0.965	0.816
	UC	0.967	0.794	0.991	0.944

The bold binary parameter denotes to what the hazard ratio is referring to. Items with P-value < 0.1 in univariate analysis were entered into the multivariate model. CD: Crohn’s disease; EIM: Extraintestinal manifestation; GI: Gastrointestinal tract; UC: Ulcerative colitis.