Vonoprazan-amoxicillin dual therapy for Helicobacter pylori eradication in Chinese population: A prospective, multicenter, randomized, two-stage study

Table 2 Adverse events for each regimen, n (%)

Adverse events	BQT	VAT-10	VAT-14	P value
				Total	BQT vs VAT-10	BQT vs VAT-14
Total	38 (37.62)	25 (25.27)	14 (13.73)	< 0.001	0.112	0.001
Bitter taste	19 (18.81)	4 (3.88)	6 (5.88)	< 0.001	0.005	0.019
Nausea	15 (14.85)	4 (3.88)	4 (3.92)	0.003	0.042	0.042
Dizziness	15 (14.85)	4 (3.88)	2 (1.96)	< 0.001	0.028	0.007
Diarrhea	11 (10.89)	4 (3.88)	10 (9.80)	0.144	-	-
Abdominal discomfort	11 (10.89)	1 (0.97)	4 (3.92)	0.005	0.020	0.206
Abdominal pain	10 (9.90)	4 (3.88)	7 (6.86)	0.236	-	-
Anorexia	10 (9.90)	3 (2.91)	2 (1.96)	0.022	0.158	0.107
Constipation	9 (8.91)	6 (5.83)	5 (4.90)	0.481	-	-
Belching	9 (8.91)	2 (1.94)	4 (3.92)	0.062	-	-
Vomiting	8 (7.92)	1 (0.97)	4 (3.92)	0.040	0.114	0.719
Skin rash	7 (6.93)	1 (0.97)	2 (1.96)	0.054	-	-
Bloating	7 (6.93)	6 (5.83)	4 (3.92)	0.638	-	-
Heartburn	7 (6.93)	1 (0.97)	3 (2.94)	0.060	-	-
Insomnia	6 (5.94)	1 (0.97)	3 (2.94)	0.107	-	-

VAT: Vonoprazan-amoxicillin dual therapy; BQT: Bismuth quadruple therapy.