Loss of monopolar spindle-binding protein 3B expression promotes colorectal cancer invasiveness by activation of target of rapamycin kinase/autophagy signaling

doi:10.3748/wjg.v30.i26.3229

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 14, 2024; 30(26): 3229-3246
Published online Jul 14, 2024. doi: 10.3748/wjg.v30.i26.3229

Table 2 Downregulation of monopolar spindle-binding protein 3B expression in colorectal cancer vs normal tissues, n (%)

MOB3B protein	CRC, n = 102	Normal tissues, n = 60	P value
Negative (-)	53 (52.0)	16 (26.7)	0.002^a
Positive (+)	49 (48.0)	44 (73.3)	0.002^a

^aP < 0.05, χ² test.

MOB3B: Monopolar spindle-binding protein 3B; CRC: Colorectal cancer.

Citation: Sun J, Zhang JX, Li MS, Qin MB, Cheng RX, Wu QR, Chen QL, Yang D, Liao C, Liu SQ, Huang JA. Loss of monopolar spindle-binding protein 3B expression promotes colorectal cancer invasiveness by activation of target of rapamycin kinase/autophagy signaling. World J Gastroenterol 2024; 30(26): 3229-3246
URL: https://www.wjgnet.com/1007-9327/full/v30/i26/3229.htm
DOI: https://dx.doi.org/10.3748/wjg.v30.i26.3229