Effect and mechanism of Qingre Huashi decoction on drug-resistant Helicobacter pylori

Figure 4 Bacteriostatic and bactericidal effects of Qingre Huashi decoction on Helicobacter pylori. A: Inhibitory kinetics show that Qingre Huashi decoction (QHD) inhibited the growth of Helicobacter pylori (HP) in a time- and dose-dependent manner. At a concentration of 16 mg/mL (1/4 MIC), QHD significantly inhibited the growth of HP. After intervention with QHD at concentrations of 32 mg/mL (1/2 MIC) and 64 mg/mL (MIC), no significant increase was found in the concentration of HP in the liquid culture medium, indicating that HP did not grow under these conditions; B: Transmission electron microscopy showing that the cell membranes of the five groups of HP exhibited varying degrees of differences, which indicated different levels of damage. OD: Optical density.