Histopathological impact of SARS-CoV-2 on the liver: Cellular damage and long-term complications

Figure 2 Direct coronavirus disease 2019 liver injury is observed through various histopathological changes. After analyzing several cohorts of liver biopsies, the most common findings associated with severe acute respiratory syndrome coronavirus 2 hepatic infection were reported and described. I: Centrilobular areas of confluent necrosis. II: The inflammatory infiltrate surrounding necrosis showed lymphoplasmacytic infiltrate with histiocytes, few eosinophils, and neutrophils. III: Periportal fibrosis and presence of both micro and macrovesicular steatosis. IV: Ballooning degeneration shown by swelling and rounding up of hepatocytes. V: Canalicular cholestasis with discrete ductular reaction, predominantly in zone 3. VI: Chronic venous congestion, endotheliitis, portal vein thrombosis and platelet-fibrin thrombi in hepatic sinusoids.