Heparin is an effective treatment for preventing liver failure after hepatectomy

Table 3 Univariate and multivariate analyses of factors associated with liver failure in matched groups

Factors	B	SE	Wald	OR (95%CI)	P value
Univariate
Heparin	-0.571	0.263	4.703	0.565 [0.337, 0.947]	0.030
Gender	-0.231	0.267	0.749	0.794 [0.470, 1.340]	0.387
Age	-0.009	0.008	1.099	0.991 [0.975, 1.008]	0.294
Height	0.021	0.014	2.055	1.021 [0.992, 1.050]	0.152
Weight	0.026	0.008	9.392	1.026 [1.009, 1.043]	0.002
Malignant tumor	-0.169	0.287	0.347	0.845 [0.482, 1.481]	0.556
Laparoscopic	-0.802	0.468	2.929	0.449 [0.179, 1.123]	0.087
Smoking	0.032	0.252	0.016	1.032 [0.630, 1.691]	0.900
Ethnicity	-0.361	0.274	1.732	0.697 [0.407, 1.193]	0.188
Hypertension	0.085	0.258	0.108	1.088 [0.656, 1.804]	0.743
PVTT	1.207	0.426	8.003	3.343 [1.451, 7.703]	0.005
Diabetes	0.891	1.232	0.523	2.437 [0.218, 27.243]	0.469
Cirrhosis	0.635	0.276	5.319	1.888 [1.100, 3.239]	0.021
Portal hypertension	0.854	0.310	7.579	2.348 [1.279, 4.312]	0.006
COPD	0.389	0.631	0.380	0.678 [0.197, 2.334]	0.537
CKD	0.465	0.388	1.440	1.592 [0.745, 3.404]	0.230
Transfusion	1.565	0.275	32.311	4.783 [2.788, 8.205]	0.000
Laboratory tests
TBIL	0.068	0.017	15.985	1.070 [1.035, 1.107]	0.000
AST	0.000	0.000	2.462	1.000 [1.000, 1.001]	0.117
ALT	0.000	0.000	0.308	1.000 [1.000, 1.001]	0.579
LDH	0.000	0.000	3.279	1.000 [1.000, 1.000]	0.070
ALB	-1.020	0.218	21.989	0.360 [0.235, 0.552]	0.000
Cr	0.054	0.105	0.264	1.056 [0.859, 1.298]	0.608
BUN	-0.005	0.008	0.457	0.995 [0.979, 1.010]	0.499
GFR	-0.005	0.008	0.457	0.995 [0.979, 1.010]	0.499
WBC	0.025	0.016	2.278	1.025 [0.993, 1.058]	0.131
PLT	-0.006	0.002	13.876	0.994 [0.991, 0.997]	0.000
INR	0.529	0.158	11.266	1.697 [1.246, 2.312]	0.001
PT	0.049	0.014	11.643	1.050 [1.021, 1.081]	0.001
APTT	0.010	0.007	1.797	1.010 [0.996, 1.024]	0.180
Multivariate
Heparin	-0.657	0.287	5.236	0.518 [0.295, 0.910]	0.022
PVTT	1.342	0.482	7.734	3.825 [1.486, 9.844]	0.005
Transfusion	1.199	0.297	16.248	3.316 [1.851, 5.940]	< 0.000
TBIL	0.048	0.019	6.558	1.050 [1.011, 1.089]	0.010
ALB	-0.749	0.239	9.815	0.473 [0.296, 0.755]	0.002

The initial screening via univariable logistic regression analysis; all variables with P < 0.1 are considered as potential risk factors, and then allowed in the multivariable analysis with a backward stepwise selection process. Factors with P < 0.05 (the bold) in the final multivariate model means significance. PVTT: Portal vein tumor thrombus; PSM: Propensity score matching; COPD: Chronic obstructive pulmonary disease; CKD: Chronic kidney disease; RBC: Red blood cell; TBIL: Total bilirubin; AST: Aspartate transaminase; ALT: Alanine transaminase; LDH: Lactate dehydrogenase; ALB: Albumin; Cr: Serum creatinine; BUN: Blood urea nitrogen; GFR: Glomerular filtration rate; WBC: White blood cell; INR: International normalized ratio; PLT: Platelets; PT: Prothrombin time; APTT: Activated partial thromboplastin time.