Preclinical and clinical evidence of the association of colibactin-producing Escherichia coli with anxiety and depression in colon cancer

Figure 2 Clinical data of colon cancer patients stratified according to the presence of colibactin-producing Escherichia coli. A: The correlation circles obtained via factor analysis of the mixed data show the correlations between the variables. The shorter vectors represent variables with weak correlations and less contribution to the axis; B: Patient representation (one point for each patient) reveals two different patient profiles according to the presence of colibactin-producing Escherichia coli (CoPEC) in the digestive tract and variables associated with the profiles. Patients with CoPEC are presented in blue, while patients without CoPEC are presented in red. The variables associated with the presence of CoPEC were past psychiatric disorders and higher Hamilton Anxiety Rating Scale (HAMA) somatic scores. Age: Age of patient; HAMA_psy: Hamilton psychologic anxiety score; HAMA_soma: Hamilton somatic anxiety score; HDRS: Hamilton Depression Rating Scale; Psy-: No past psychiatric disorder; Psy+: Past psychiatric disorder; Stage: TNM stage of tumor.