Hydrogen-rich water alleviates constipation by attenuating oxidative stress through the sirtuin1/nuclear factor-erythroid-2-related factor 2/heme oxygenase-1 signaling pathway

doi:10.3748/wjg.v30.i20.2709

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May 28, 2024 (publication date) through Jan 25, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 28, 2024; 30(20): 2709-2725
Published online May 28, 2024. doi: 10.3748/wjg.v30.i20.2709

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Figure 1 Overview of the workflow. Nor: Normal group; Lop: Loperamide-induced constipation group; HRW: Hydrogen-rich water intervention group; SIRT1: Sirtuin1; Nrf2: Nuclear factor-erythroid-2-related factor 2; HO-1: Heme oxygenase-1; ROS: Reactive oxygen species; MDA: Malondialdehyde; SOD: Superoxide dismutase; AB-PAS: Alcian blue-periodic acid-Schiff; c-kit: Cell growth factor receptor kit; β-Leu: β-leucine; TA: Traumatic acid; SD rats: Sprague-Dawley rats.

Citation: Chen KD, Wang KL, Chen C, Zhu YJ, Tang WW, Wang YJ, Chen ZP, He LH, Chen YG, Zhang W. Hydrogen-rich water alleviates constipation by attenuating oxidative stress through the sirtuin1/nuclear factor-erythroid-2-related factor 2/heme oxygenase-1 signaling pathway. World J Gastroenterol 2024; 30(20): 2709-2725
URL: https://www.wjgnet.com/1007-9327/full/v30/i20/2709.htm
DOI: https://dx.doi.org/10.3748/wjg.v30.i20.2709