Kinesin 26B modulates M2 polarization of macrophage by activating cancer-associated fibroblasts to aggravate gastric cancer occurrence and metastasis

Figure 1 Overexpression of KIF26B in gastric cancer and its poor prognosis. A: The heat map shows the TCGA expression profile of all Kinesin superfamily proteins (normal and tumor tissues), with a total of 18 DEGs; B: The gene KIF26B with the most significant differential expression in gastric cancer (GC) was screened, and survival analysis was conducted; C: A pan-cancer analysis was conducted on KIF26B in various cancers; D: Using quantitative real-time polymerase chain reaction to detect the expression of KIF26B in GC tissue and adjacent tissues (n = 50); E: Immunohistochemical analysis of the expression of KIF26B in GC tissue and adjacent tissues (n = 3); F: The protein expression levels of KIF26B in GC cell lines (HGC-27/AGS) and normal gastric mucosal epithelial cell line (GES-1) were detected by western blotting (n = 3). ^aP < 0.05, ^bP < 0.01. GC: Gastric cancer.