Development and validation of a new prognostic model for patients with acute-on-chronic liver failure in intensive care unit

Table 2 Risk factors for 28-day mortality in acute-on-chronic liver failure patients from Medical Information Mart for Intensive Care-derivation set

Variable	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Female	1.08 (0.88-1.33)	0.47
Ln (age)	2.18 (1.32-3.61)	0.002	9.14 (5.16-16.19)	< 0.001
Race (Non-white)	1.15 (0.93-1.41)	0.20
Cirrhosis etiology (non-alcohol)	1.00 (0.82-1.23)	0.998
Ln (MAP)	0.03 (0.01-0.06)	< 0.001	0.06 (0.03-0.14)	< 0.001
Organ failures
Circulatory failure	1.87 (1.53-2.29)	< 0.001
Respiratory failure	1.56 (1.27-1.93)	< 0.001	1.84 (1.48-2.29)	< 0.001
Cerebral failure	1.63 (1.26-2.11)	< 0.001	1.36 (1.05-1.77)	0.02
Renal failure	1.89 (1.53-2.34)	< 0.001	1.68 (1.36-2.09)	< 0.001
Liver failure	2.31 (1.67-2.50)	< 0.001
Coagulation failure	2.04 (1.87-2.84)	< 0.001
Laboratory indicators
Ln (WBC)	1.58 (1.33-1.88)	< 0.001	1.25 (1.05-2.10)	0.01
Ln (hemoglobin)	0.65 (0.44-0.97)	0.04
Ln (platelet)	0.84 (0.73-0.97)	0.02
Ln (TB)	1.50 (1.38-1.63)	< 0.001	1.57 (1.42-1.73)	< 0.001
Ln (Albumin)	0.68 (0.45-1.04)	0.07
Ln (ALT)	1.04 (0.97-1.12)	0.29
Ln (AST)	1.09 (1.02-1.17)	0.01
Ln (INR)	1.27 (1.20-1.33)	< 0.001	1.82 (1.43-2.32)	< 0.001
Ln (sodium)	0.04 (0.01-0.23)	< 0.001
Ln (potassium)	2.05 (1.23-3.41)	0.006	1.84 (1.10-3.07)	0.02

Bold font indicates statistical differences. MAP: Mean arterial pressure; WBC: White blood cell; TB: Total bilirubin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; INR: International normalized ratio.