Novel lactylation-related signature to predict prognosis for pancreatic adenocarcinoma

Figure 9 SLC16A1 promotes L-lactylation in pancreatic cancer. A: L-lactylation levels in normal and pancreatic ductal adenocarcinoma (PDAC) cell lines; B and C: Intracellular lactate and western blotting of lactylation under different concentration of lactate; D: Expression of lactylation-related genes (LRGs) in normal and PDAC cell lines; E: Expression of SLC16A1 in normal and PDAC cell lines; F-G: Intracellular lactate and western blotting of lactylation treated with different concentration of α-cyano-4-hydroxycinnamic acid (CHC); H: Expression of histone L-lactylation in pancreatic cancer treated with lactate and CHC. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, ^dP < 0.0001. CHC: Α-cyano-4-hydroxycinnamic acid; PDAC: Pancreatic adenocarcinoma.