HepG2.2.15-derived exosomes facilitate the activation and fibrosis of hepatic stellate cells

Figure 4 Differential miRNA expression in HepG2. 2.15-derived exosomes. A: The volcano plot demonstrates the differentially expressed miRNAs between HepG2.2.15-derived exosomes and HepG2-derived exosomes. Using a threshold of a P value less than 0.05 and absolute value of log₂FC exceeding one, the up-regulated miRNAs are illustrated in red, while down-regulated miRNAs are in green; B: A heat map represents alterations in the expression of the differential miRNAs between HepG2.2.15-derived and HepG2-derived exosomes; with the colour red symbolising up-regulated miRNAs and blue indicating down-regulated miRNAs; C: The Gene Ontology enrichment analysis provides an insightful look into the respective target genes of the differentially expressed miRNAs; D: Enriched Kyoto Encyclopedia of Genes and Genomes pathway statistics are shown in scatter plots, highlighting the top 20 enriched pathways for an easy comparison and further analysis. GO: Gene Ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes; HBV: Hepatitis B virus; FC: Fold change.