Non-pancreatic hyperlipasemia: A puzzling clinical entity

Table 7 Performance characteristics of lipase in identifying acute pancreatitis in various clinical settings

	Cut-off values (U/L)	Sensitivity (%)	Specificity (%)	LR+	LR-	PPV (%)	NPV (%)
AP overall	> 666	71.4	88.8	6.37	0.32	86.2	76.1
AP without complications	> 666	71.1	95.0	14.16	0.30	94.9	71.4
AP with sepsis	> 861	64.3	88.3	5.49	0.40	73.5	83.1
AP with AKI	> 951	58.5	92.5	7.79	0.45	70.6	87.9
AP with AKI or sepsis	> 722	71.9	90.0	7.19	0.31	83.7	81.8
AP with both complications	> 1587	50.0	97.6	20.5	0.51	83.3	88.9

AP: Acute pancreatitis; NPHL: Non-pancreatic hyperlipasemia; LR+: Positive likelihood ratio; LR-: Negative likelihood ratio; PPV: Positive predictive value; NPV: Negative predictive value; AKI: Acute kidney injury.