Clinical manifestations, diagnosis and long-term prognosis of adult autoimmune enteropathy: Experience from Peking Union Medical College Hospital

doi:10.3748/wjg.v30.i19.2523

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Gastroenterol. May 21, 2024; 30(19): 2523-2537
Published online May 21, 2024. doi: 10.3748/wjg.v30.i19.2523

Table 2 Demographic and clinical manifestations of adult autoimmune enteropathy patients

Onset age (yr)		45.5 (IQR: 30.8-53.5)
Diarrhea duration (months)		4.0 (IQR: 2.0-6.0)
Weight loss (kg)		17.0 (IQR: 11.3-29.0)
BMI (kg/m²)		17.9 (IQR: 16.4-19.1)
Vomit		81% (13/16)
Abdominal pain		50% (8/16)
Fever		50% (8/16)
Hypovolemic shock		38% (6/16)
Wernicke encephalopathy		19% (3/16)
Acute kidney injury		50% (8/16)
Anemia	Anemia	81% (13/16)
	Mild	44% (7/16)
	Moderate	31% (5/16)
	Severe	6% (1/16)
Hypoalbuminemia		88% (14/16)
Electrolyte disturbance	Hypokalemia	94% (15/16)
	Hyponatremia	69% (11/16)
	Hypocalcemia	94% (15/16)
	Hypomagnesemia	44% (4/9)
Endocrine disorders	Thyroid dysfunction	14% (2/14)
Endocrine disorders	Abnormal blood glucose	0% (0/14)
Inflammatory indicators	Elevated WBC	75% (12/16)
	Elevated hsCRP	50% (8/16)
	Elevated ESR	50% (8/16)
Liver function	Elevated ALT	50% (8/16)
Fecal OB test	Positive	81% (13/16)
Fecal OB test	Negative	19% (3/16)
Fecal Sultan III staining	Positive	56% (9/16)
Fecal Sultan III staining	Negative	44% (7/16)
D-xylose absorption test	Positive	100% (13/13)
Complement	Decreased C3	73% (11/15)
Complement	Decreased C4	7% (1/15)
IgA	Elevated	25% (4/16)
IgA	Normal	75% (12/16)
IgM	Elevated	6% (1/16)
	Decreased	25% (4/16)
	Normal	69% (11/16)
IgG	Elevated	19% (3/16)
IgG	Normal	81% (13/16)
IgE	Elevated	43% (3/7)
IgE	Normal	57% (4/7)
AE antibody		0% (0/2)
AG antibody		0% (0/6)
Other antibodies	Celiac	8% (1/13)
	ANA	7% (1/14)
	ANCA	8% (1/13)

IQR: Interquartile range; BMI: Body mass index; WBC: White blood cell; hsCRP: High-sensitivity C-reactive protein; ESR: Erythrocyte sedimentation rate; ALT: Alanine transferase; Fecal OB test: Fecal occult blood test; IgA: Immunoglobulin A; IgM: Immunoglobulin M; IgG: Immunoglobulin G; IgE: Immunoglobulin E; AE: Anti-enterocyte; AG: Anti–goblet cell; ANA: Antinuclear antibodies; ANCA: Anti-neutrophil cytoplasmic antibody; IBD: Inflammatory bowel disease; ASCA: Anti-Saccharomyces cerevisiae antibodies; APAB: Anti-pancreatic antibody.

Citation: Li MH, Ruan GC, Zhou WX, Li XQ, Zhang SY, Chen Y, Bai XY, Yang H, Zhang YJ, Zhao PY, Li J, Li JN. Clinical manifestations, diagnosis and long-term prognosis of adult autoimmune enteropathy: Experience from Peking Union Medical College Hospital. World J Gastroenterol 2024; 30(19): 2523-2537
URL: https://www.wjgnet.com/1007-9327/full/v30/i19/2523.htm
DOI: https://dx.doi.org/10.3748/wjg.v30.i19.2523