Salivary metabolites are promising noninvasive biomarkers of drug-induced liver injury

Figure 4 Area under the receiver operating characteristic curves and hub metabolite screening of machine learning algorithms for significantly different metabolites. A: Area under the receiver operating characteristic (AUROC) curve of the least absolute shrinkage and selection operator (LASSO) model; B: AUROC curve of the random forest (RF) model; C: Hub metabolite screening of LASSO; D: Hub metabolite screening of RF. LASSO: Least absolute shrinkage and selection operator; RF: Random forest; AUC: Area under the curve; ROC: Receiver operating characteristic.