Salivary metabolites are promising noninvasive biomarkers of drug-induced liver injury

Figure 1 Multivariate statistical analysis. A: Principal component analysis (PCA) scatter plots of the two groups in positive mode; B: PCA scatter plots of the two groups in negative mode; C: Partial least squares-discriminant analysis (PLS-DA) scatter plots of the two groups in positive mode; D: PLS-DA scatter plots of the two groups in negative mode; E: Cross-validation plot of the two groups with a permutation test repeated 200 times in positive mode; F: Cross-validation plot of the two groups with a permutation test repeated 200 times in negative mode. Healthy controls group (n = 35, blue circles), drug-induced liver injury group (n = 31, red circles). PCA: Principal component analysis; PLS-DA: Partial least squares-discriminant analysis.