Overlapping approach Proton Pump Inhibitors/Nux vomica-Heel as new intervention for gastro-esophageal reflux management: Delphi consensus study

Table 1 Characteristics and actions of the medication object of the Delphi consensus, Nux vomica-Heel

Characteristics of Nux vomica-Heel
Nux vomica-Heel tablets (also marketed as Gastricumeel®, Biologische Heilmittel Heel GmbH, Baden-Baden - Germany) is a natural, multicomponent low dose medication consisting of six ingredients from the homeopathic tradition useful for the treatment of bloating, acid reflux, and other symptoms as well as for heartburn
Each component of Nux vomica-Heel, according to literature (basic research), exerts a cohort of function
Nux vomica: Modulation of acid secretion[16-19]
Pulsatilla: Modulation of mucosal inflammation; modulation of mucosal secretions[21]
Antimonium crudum: Modulation of mucosal inflammation[22,23]
Argentum nitricum: Modulation of mucosal inflammation; increased EGF (Epidermal Growth Factor) release[24,25]
Arsenicum album: Modulation of mucosal inflammation; reduced VEGF (Vasal Endothelial Growth Factor) release[26,27]
Carbo vegetabilis: Chelation of toxins[28,29]
According to the composition, three can be the main actions of Nux vomica-Heel:
(1) Aetiologic, through a direct modulation of acid secretion
(2) Symptomatic, through the modulation of gastric mucosa acute inflammation
(3) Preventive, through the modulation of gastric mucosa inflammation progression