FibroScan-aspartate transaminase: A superior non-invasive model for diagnosing high-risk metabolic dysfunction-associated steatohepatitis

Table 5 The comparison between the subgroup and the remaining population

Project	Subgroup population	Remaining population	P value
	(n = 117)	(n = 162)
Demographics
Male	49 (41.9)	77 (47.5)	0.35
Age (yr)	44.0 (32.0, 53.0)	40.0 (30.0, 53.3)	0.38
BMI (kg/m2)	26.4 ± 3.4	27.6 ± 3.4	0.08
Metabolic disease
Dysglycemia	80 (68.4)	107 (66.0)	0.68
Hypertension	33 (28.2)	39 (24.1)	0.44
Hyperlipidemia	21 (17.9)	16 (9.9)	0.05
Hypertriglyceridemia	69 (59.0)	81 (50.0)	0.14
Low HDL	89 (76.1)	113 (69.8)	0.24
Serologic indicators
TC (mmol/L)	5.0 ± 1.0	4.8 ± 1.0	0.19
TG (mmol/L)	2.0 (1.3, 2.9)	1.7 (1.3, 2.5)	0.46
HDL-C (mmol/L)	1.0 (0.9, 1.2)	1.0 (0.9, 1.2)	0.98
LDL-C (mmol/L)	3.0 ± 0.9	2.9 ± 0.8	0.43
Fasting blood glucose (mmol/L)	5.9 (5.5, 6.8)	5.8 (5.3, 6.7)	0.38
PLT (× 109/L)	229.2 ± 71.1	218.1 ± 62.0	0.17
ALT (U/L)	72.5 (46.0, 125.0)	100.1 (62.7, 152.6)	0.01
AST (U/L)	46.2 (29.8, 77.4)	52.5 (34.9, 83.1)	0.11
ALP (U/L)	77.6 (66.1, 98.1)	83.6 (65.6, 101.2)	0.49
GGT (U/L)	71.4 (43.5, 105.1)	58.6 (37.5, 103.2)	0.25
TBIL (μmol/L)	12.4 (9.5, 16.4)	12.3 (9.2, 16.7)	0.88
ALB (g/L)	46.6 (42.7, 49.0)	45.6 (43.1, 48.9)	0.41
HGB (g/L)	145.0 (136.0, 156.0)	143.5 (131.0, 156.1)	0.16
Apolipoprotein A1 (g/L)	1.4 (1.2, 1.5)	1.3 (1.1, 1.5)	0.22
Apolipoprotein B (g/L)	1.0 (0.8, 1.1)	0.9 (0.7, 1.1)	0.10
Cr (μmol/L)	61.5 (52.7, 71.3)	61.5 (52.0, 73.1)	0.93
Urea (mmol/L)	4.5 (3.8, 5.2)	4.7 (3.8, 5.4)	0.41
Uric acid (μmol/L)	369.0 (304.0, 436.5)	363.5 (296.0, 433.0)	0.64
eGFR (mL/min)	112.5 (103.4, 120.2)	107.0 (98.5, 119.5)	0.24
PT (s)	11.3 (10.7, 11.9)	11.3 (10.6, 11.9)	0.90
Non-invasive models
FIB-4	1.0 (0.6, 1.6)	0.9 (0.6, 1.6)	0.88
APRI	0.5 (0.3, 1.0)	0.6 (0.4, 1.0)	0.08
Forns index	4.4 (3.0, 5.6)	4.1 (3.0, 5.7)	0.74
ARR	0.6 (0.5, 0.8)	0.5 (0.4, 0.7)	0.06
S index	0.1 (0.1, 0.2)	0.1 (0.1, 0.3)	0.53
GPR	0.7 (0.5, 1.2)	0.7 (0.4, 1.2)	0.45

All data are presented as n (%) or mean ± SD or M (P25, P75). BMI: Body mass index; HDL-C: High density lipoprotein cholesterol; TC: Total cholesterol; TG: Triglycerides; LDL-C: Low density lipoprotein cholesterol; PLT: Platelets; ALT: Alanine transaminase; AST: Aspartate transaminase; ALP: Alkaline phosphatase; GGT: Gamma-glutamyl transferase; TBIL: Total bilirubin; ALB: Albumin; HGB: Hemoglobin; Cr: Creatinine; eGFR: Estimated glomerular filtration rate; PT: Prothrombin time; FIB-4: Fibrosis-4; APRI: Aspartate transaminase to platelet ratio index; ARR: Aspartate transaminase to alanine transaminase ratio; GPR: Gamma-glutamyl transpeptidase to platelet ratio.