Minocycline in the eradication of Helicobacter pylori infection: A systematic review and meta-analysis

Figure 1 Scheme of the minocyclines’ mechanism of action. Amino acids and tRNAs are linked together by aminoacyl-tRNA synthetase to produce specific Aminoacyl-tRNAs. ribosomes on the ribosomal complex then read the code along the 5’-3’ direction of the mRNAs while linking various aminoacyl-tRNA-transported amino acids according to the instructions of the mRNA coding sequences for the process of protein synthesis. When minocycline enters into bacteria, it specifically binds to the A site of bacterial ribosomal 30S subunit aminoacyl group, thus blocking the aminoacyl-tRNA binding at this site, preventing peptide chain elongation and bacterial protein synthesis, and exerting bactericidal effects. AA: Amino acids.