Chitin-glucan improves important pathophysiological features of irritable bowel syndrome

Figure 3 Time- and dose-related analgesic effects of chitin-glucan in rats with long-lasting TNBS-induced hypersensitivity. Inhibition of pain perception in % at week (W) 0-3-5-7 compared to W-2 in untreated animals receiving tap water (Control in blue), untreated animals sensitized by TNBS (TNBS in black), TNBS sensitized rats treated with phloroglucinol (Phloro in grey), TNBS sensitized rats treated with chitin-glucan at 1.5 g/d [chitin glucan (CG) 1.5 g/d in green], TNBS sensitized rats treated with chitin-glucan at 3.0 g/d (CG 3.0 g/d in orange). ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. CG: Chitin glucan.