Editorial
Copyright ©The Author(s) 2024.
World J Gastroenterol. Apr 28, 2024; 30(16): 2184-2190
Published online Apr 28, 2024. doi: 10.3748/wjg.v30.i16.2184
Table 2 Barriers to the use of microRNAs in clinical practice
High exam cost
Better definition of miRNAs as diagnostic markers in IBD (differentiation between UC and CD and diagnosis of disease activity)
Few validation studies of miRNAs as blood, fecal, and endoscopic biomarkers
Better definition of the differences between the expression of fecal, blood, and tissue miRNAs
Lack of evidence validating miRNAs as a tool for evaluating mucosal healing
Lack of evidence validating miRNAs as a tool for evaluating histological remission
Lack of evidence validating miRNAs predictors of clinical and endoscopic responses
Lack of evidence validating miRNAs in treatment monitoring
Lack of evidence validating miRNAs as predictors of severe disease
Insufficient data on the role of miRNAs in modulating the inflammatory response
Insufficient data on the effects of miRNAs on the intestinal barrier, intestinal microbiota, and the response to probiotics