Taurine attenuates activation of hepatic stellate cells by inhibiting autophagy and inducing ferroptosis

doi:10.3748/wjg.v30.i15.2143

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 21, 2024; 30(15): 2143-2154
Published online Apr 21, 2024. doi: 10.3748/wjg.v30.i15.2143

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Figure 5 Mechanisms associated with taurine-mediated death and inactivation of hepatic stellate cells in liver fibrosis. A: Inhibition of autophagy; B: Activation of ferritinophagy; C: Induction of ferroptosis. FTH1: Ferritin heavy chain 1; NCOA4: Nuclear receptor coactivator 4; ROS: Reactive oxygen species; HSC: Hepatic stellate cell; GSH: Glutathione.

Citation: Li S, Ren QJ, Xie CH, Cui Y, Xu LT, Wang YD, Li S, Liang XQ, Wen B, Liang MK, Zhao XF. Taurine attenuates activation of hepatic stellate cells by inhibiting autophagy and inducing ferroptosis. World J Gastroenterol 2024; 30(15): 2143-2154
URL: https://www.wjgnet.com/1007-9327/full/v30/i15/2143.htm
DOI: https://dx.doi.org/10.3748/wjg.v30.i15.2143