Comparative transcriptomic analysis reveals the molecular changes of acute pancreatitis in experimental models

Figure 1 Treatment with caerulein alone or in combination with lipopolysaccharide induced varying degrees of experimental acute pancreatitis. Modeling methods for the control group, caerulein (CAE) group, and CAE combined with lipopolysaccharide (LPS; CAE + LPS) group, evaluation of pancreatic tissue changes, and relevant parameters. A: Schematic representation of the modeling methods for the CAE group and CAE + LPS group; B: Pancreatic weight ratios in the three groups; C: H&E staining of pancreatic tissue; D: Scores for edema, inflammation, and necrosis in pancreatic pathology; E-G: Quantitative real-time PCR expression values of pancreatic inflammatory factors. n = 6 per group, ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. CAE: Caerulein; CON: Control; LPS: Lipopolysaccharide.