Fusobacterium nucleatum-induced imbalance in microbiome-derived butyric acid levels promotes the occurrence and development of colorectal cancer

Figure 11  Adenosine monophosphate-activated protein kinase-specific small interfering RNA prevented cycle arrest caused by sodium butyrate. A and B: Sodium butyrate (NaB) arrested the cell cycle of DLD-1 and HCT116 cells in the G2/M phase, while adenosine monophosphate-activated protein kinase small interfering RNA (siRNA) transfection inhibited this phenomenon. ns: P > 0.05, ^cP < 0.001. p-AMPK: Phosphorylated adenosine monophosphate-activated protein kinase.