Fusobacterium nucleatum-induced imbalance in microbiome-derived butyric acid levels promotes the occurrence and development of colorectal cancer

Figure 10  Adenosine monophosphate-activated protein kinaseα-specific small interfering RNA inhibits the anticancer effect of sodium butyrate. A and B: Sodium butyrate (NaB) activates adenosine monophosphate-activated protein kinase (AMPK), inhibits proliferative protein expression. However, after transfection with AMPK small interfering RNA (siRNA), AMPK is knocked down, and the inhibitory function of NaB on cancer is weakened. Data are expressed as mean ± standard deviation, from at least three independent experiments. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. NC: Control; p-AMPK: Phosphorylated adenosine monophosphate-activated protein kinase.